Giselle P. Lim, PhD

 

Giselle has been an amazing team leader on projects on non-steroidal anti-inflammatory agents , and training technicians to perform Westerns and ELISA. Her enthusiatic spirit, steadfast energy and can-do attitudes bring projects to closure and have inspired some of the current clinical trials. Giselle graduated from UC Irvine with a Bachelor’s of Science degree in Biology in 1989. She began working as a staff scientist in the histology clinic at the Beckman Laser Institute and Medical Clinic at UCI soon after graduating.  In the fall of 1991, she enrolled in the Ph.D. program in the Dept of Cell and Neurology at the USC Keck School of Medicine, where she studied the expression of matrix metalloproteinases in Alzheimer’s disease and amyotrophic lateral sclerosis (ALS) under the direction of Drs. Zoltan Tokes and Michael Cullen. After a year of postdoctoral training at USC, she joined Dr. Cole’s lab in 1998 and focused on evaluating the effects of anti-inflammatory and anti-oxidant components in transgenic mouse model for Alzheimer’s disease using biochemical assays.  Her current projects focus on how essential fatty acids such as DHA can modulate the production of ßamyloid and its precursor, amyloid precursor protein in transgenic mice and neuroblastoma cells.

Extracurricular activities. Giselle enjoys marching in the Chinese New Year parade as a dragon, and going to the Griffith park carousel with her daughter, having huge parties with delicious Chinese food cooked by her father, an engineer, who in addition to engineering a secret spicy eggplant tofu & cabbage dishes, also in his spare time engineered the tables to hold the hundred of pounds of water inside our mouse and rat water maze tanks.

 

• Selected peer-reviewed publications (in chronological order).

  1.Calon F, Lim GP, Morihara T, Yang F, Ubeda O, Salem N Jr, Frautschy SA, Cole GM. Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. Eur J Neurosci. 2005 Aug;22(3):617-26.PMID: 16101743 [PubMed - in process]
  

• 2: Lim GP, Calon F, Morihara T, Yang F, Teter B, Ubeda O, Salem N Jr, Frautschy SA, Cole GM. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model.J Neurosci. 2005 Mar 23;25(12):3032-40.PMID: 15788759 [PubMed - in process]
  

• 3: Morihara T, Teter B, Yang F, Lim GP, Boudinot S, Boudinot FD, Frautschy SA, Cole GM. Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models.
  Neuropsychopharmacology. 2005 Jun;30(6):1111-20. PMID: 15688088 [PubMed - indexed for MEDLINE]
  

• 4: Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA. NSAID and Antioxidant Prevention of Alzheimer's Disease: Lessons from In Vitro and Animal Models.
  Ann N Y Acad Sci. 2004 Dec;1035:68-84.PMID: 15681801 [PubMed - in process]
  

• 5: Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ, Frautschy SA, Cole GM. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.
  J Neurosci. 2004 Dec 8;24(49):11120-6.PMID: 15590928 [PubMed - indexed for MEDLINE]
  

• 6: Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
  J Biol Chem. 2005 Feb 18;280(7):5892-901. Epub 2004 Dec 7. PMID: 15590663 [PubMed - indexed for MEDLINE]
  

• 7: Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N Jr, Ashe KH, Frautschy SA, Cole GM. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model.
  Neuron. 2004 Sep 2;43(5):633-45.PMID: 15339646 [PubMed - indexed for MEDLINE]
  

• 8: Harris-White ME, Balverde Z, Lim GP, Kim P, Miller SA, Hammer H, Galasko D, Frautschy SA Role of LRP in TGFbeta2-mediated neuronal uptake of Abeta and effects on memory.
  J Neurosci Res. 2004 Jul 15;77(2):217-28. PMID: 15211588 [PubMed - indexed for MEDLINE]
  

• 9: Lim GP, Yang F, Chu T, Gahtan E, Ubeda O, Beech W, Overmier JB, Hsiao-Ashec K, Frautschy SA, Cole GM. Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice.
  Neurobiol Aging. 2001 Nov-Dec;22(6):983-91.PMID: 11755007 [PubMed - indexed for MEDLINE]
  

• 10: Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 1;21(21):8370-7.PMID: 11606625 [PubMed - indexed for MEDLINE]
  

• 11: Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA, Cole GM. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.
  J Neurosci. 2000 Aug 1;20(15):5709-14.PMID: 10908610 [PubMed - indexed for MEDLINE]
  

• 12: Lim GP, Russell MJ, Cullen MJ, Tokes ZA. Matrix metalloproteinases in dog brains exhibiting Alzheimer-like characteristics.J Neurochem. 1997 Apr;68(4):1606-11.PMID: 9084432 [PubMed - indexed for MEDLINE]
  

• 13: Backstrom JR, Lim GP, Cullen MJ, Tokes ZA. Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).
  J Neurosci. 1996 Dec 15;16(24):7910-9.
  PMID: 8987819 [PubMed - indexed for MEDLINE]
  

• 14: Lim GP, Backstrom JR, Cullen MJ, Miller CA, Atkinson RD, Tokes ZA. Matrix metalloproteinases in the neocortex and spinal cord of amyotrophic lateral sclerosis patients.
  J Neurochem. 1996 Jul;67(1):251-9.
  PMID: 8666998 [PubMed - indexed for MEDLINE]