Edmond Teng, MD, PhD

Email: eteng@ucla.edu


Research Lab


UCLA Dept Medicine

Dr. Teng joined our team with a strong background in clinical neurology as well as behavioral science. He received his BS in Chemistry at Stanford University in 1993. He received a MD in 1998 and also a PhD in 2000 both from UCSD working with reknowned cognitive scientists Larry Squire and Stuart Zola. After completing his MD , he entered the internship program at UCLA in the Dept of Medicine. He completed a residency in 2005 in Neurology and a fellowship in the Dementia and Behavioral Neuroscience Research Program in 2007 with world renowned Alzheimer's expert Jeffery Cummings, founding director of the Ruvo Institute. He is now a Special Fellow in Geriatric Neurology in Clinical Neurology and attending physician. He has received two Alzheimer's research awards (UCLA Alzheimer Disease Research Award) and a French Foundation award to pursue research in Alzheimer's disease. In addition to running research on cognitive impact of Alzheimer's mutation in rodent models and impact of dietary interventions, he is also leading the analysis of biomarkers for the clinical trial using curcumin.


Dr. Teng participated in the Alzheiemer' breaktrough ride in 2011. Here he is with Dr Karen Gylys, Associate Professor of Nursing, UCLA

Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.Ma QL, Zuo X, Yang F, Ubeda OJ, Gant DJ, Alaverdyan M, Kiosea NC, Nazari S, Chen PP, Nothias F, Chan P, Teng E, Frautschy SA, Cole GM. J Neurosci. 2014 May 21;34(21):7124-36. doi: 10.1523/JNEUROSCI.3439-13.2014.PMID: 24849348

Similar verbal fluency patterns in amnestic mild cognitive impairment and Alzheimer's disease. Teng E, Leone-Friedman J, Lee GJ, Woo S, Apostolova LG, Harrell S, Ringman JM, Lu PH. Arch Clin Neuropsychol. 2013 Aug;28(5):400-10. doi: 10.1093/arclin/act039. Epub 2013 Jun 9. PMID:  23752677
Interrater reliability of the new criteria for behavioral variant frontotemporal dementia. Lamarre AK, Rascovsky K, Bostrom A, Toofanian P, Wilkins S, Sha SJ, Perry DC, Miller ZA, Naasan G, Laforce R Jr, Hagen J, Takada LT, Tartaglia MC, Kang G, Galasko D, Salmon DP, Farias ST, Kaur B, Olichney JM, Quitania Park L, Mendez MF, Tsai PH, Teng E, Dickerson BC, Domoto-Reilly K, McGinnis S, Miller BL, Kramer JH. Neurology. 2013 May 21;80(21):1973-7. doi: 10.1212/WNL.0b013e318293e368. Epub 2013 May 1. PMID:23635967

 Clinicopathologic differences among patients with behavioral variant frontotemporal dementia. Mendez MF, Joshi A, Tassniyom K, Teng E, Shapira JS. Neurology. 2013 Feb 5;80(6):561-8. doi: 10.1212/WNL.0b013e3182815547. Epub 2013 Jan 16. PMID:  23325909

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Ringman JM, Frautschy SA, Teng E, Begum AN, Bardens J, Beigi M, Gylys KH, Badmaev V, Heath DD, Apostolova LG, Porter V, Vanek Z, Marshall GA, Hellemann G, Sugar C, Masterman DL, Montine TJ, Cummings JL, Cole GM. Alzheimers Res Ther. 2012 Oct 29;4(5):43. doi: 10.1186/alzrt146. eCollection 2012. PMID:  23107780

Depressive symptoms in mild cognitive impairment predict greater atrophy in Alzheimer's disease-related regions. Lee GJ, Lu PH, Hua X, Lee S, Wu S, Nguyen K, Teng E, Leow AD, Jack CR Jr, Toga AW, Weiner MW, Bartzokis G, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. Biol Psychiatry. 2012 May 1;71(9):814-21. doi: 10.1016/j.biopsych.2011.12.024. Epub 2012 Feb 8. PMID:  22322105
Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume. Carmichael O, Xie J, Fletcher E, Singh B, DeCarli C; Alzheimer's Disease Neuroimaging Initiative. Neurobiol Aging. 2012 Jun;33(6):1124.e31-41. doi: 10.1016/j.neurobiolaging.2011.08.016. Epub 2011 Dec 14. PMID: 22169204

Detecting global and local hippocampal shape changes in Alzheimer's disease using statistical shape models. Shen KK, Fripp J, Mériaudeau F, Chételat G, Salvado O, Bourgeat P; Alzheimer's DiseaseNeuroimaging Initiative Neuroimage. 2012 Feb 1;59(3):2155-66. doi: 10.1016/j.neuroimage.2011.10.014. Epub 2011 Oct 14. PMID:22037419

Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta inAlzheimer's disease and apoE TR mouse cortex. Arold S, Sullivan P, Bilousova T, Teng E, Miller CA, Poon WW, Vinters HV, Cornwell LB, Saing T, Cole GM, Gylys KH. Acta Neuropathol. 2012 Jan;123(1):39-52. doi: 10.1007/s00401-011-0892-1. Epub 2011 Oct 22.PMID: 22020632

Individual subject classification for Alzheimer's disease based on incremental learning using a spatial frequency representation of cortical thickness data. Cho Y, Seong JK, Jeong Y, Shin SY; Alzheimer's Disease Neuroimaging Initiative. Neuroimage. 2012 Feb 1;59(3):2217-30. doi: 10.1016/j.neuroimage.2011.09.085. Epub 2011 Oct 8. PMID:  22008371
Posterior cortical atrophy: evidence for discrete syndromes of early-onset Alzheimer's disease. Tsai PH, Teng E, Liu C, Mendez MF. Am J Alzheimers Dis Other Demen. 2011 Aug;26(5):413-8. doi: 10.1177/1533317511418955. Epub 2011 Aug 9. PMID: 21831859

Increasing depressive symptoms in children of Alzheimer parents. Teng E, Melrose RJ, Osato S, Jimenez E, Ercoli LM, Jarvik LF. J Geriatr Psychiatry Neurol. 2011 Sep;24(3):135-41. doi: 10.1177/0891988711409402. Epub 2011 Jun 1. PMID21633123

[F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model ofAlzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment. Teng E, Kepe V, Frautschy SA, Liu J, Satyamurthy N, Yang F, Chen PP, Cole GB, Jones MR, Huang SC, Flood DG, Trusko SP, Small GW, Cole GM, Barrio JR. Neurobiol Dis. 2011 Sep;43(3):565-75. doi: 10.1016/j.nbd.2011.05.003. Epub 2011 May 13.
PMID: 21605674

Longitudinal change in CSF biomarkers in a presymptomatic carrier of an APP mutation. Ringman JM, Taylor K, Teng E, Coppola G, Gylys K. Neurology. 2011 Jun 14;76(24):2124-5. doi: 10.1212/WNL.0b013e31821f4488. Epub 2011 May 11. No abstract available.
PMID: 21562250

Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis. McEvoy LK, Holland D, Hagler DJ Jr, Fennema-Notestine C, Brewer JB, Dale AM; Alzheimer'sDisease Neuroimaging Initiative. Radiology. 2011 Jun;259(3):834-43. doi: 10.1148/radiol.11101975. Epub 2011 Apr 6.
PMID: 21471273

Using CSF biomarkers to replicate genetic associations in Alzheimer's disease. Schott JM; ADNI Investigators. Neurobiol Aging. 2012 Jul;33(7):1486.e9-15. doi: 10.1016/j.neurobiolaging.2011.02.008. Epub 2011 Apr 3.
PMID: 21459483

Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment. Tosun D, Schuff N, Mathis CA, Jagust W, Weiner MW; Alzheimer's Disease NeuroImaging Initiative. Brain. 2011 Apr;134(Pt 4):1077-88. doi: 10.1093/brain/awr044. Epub 2011 Mar 22. PMID:21429865

Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su'a M, Fagan AM, Holtzman DM, Morris JC; Alzheimer's Disease Neuroimaging Initiative, Goate AM. PLoS One. 2011 Feb 9;6(2):e15918. doi: 10.1371/journal.pone.0015918. PMID: 21347408
Utility of the functional activities questionnaire for distinguishing mild cognitive impairment from very mild Alzheimer disease. Teng E, Becker BW, Woo E, Knopman DS, Cummings JL, Lu PH. Alzheimer Dis Assoc Disord. 2010 Oct-Dec;24(4):348-53. doi: 10.1097/WAD.0b013e3181e2fc84. PMID 20592580

Donepezil delays progression to AD in MCI subjects with depressive symptoms. Lu PH, Edland SD, Teng E, Tingus K, Petersen RC, Cummings JL; Alzheimer's Disease Cooperative Study Group. Neurology. 2009 Jun 16;72(24):2115-21. doi: 10.1212/WNL.0b013e3181aa52d3. PMID:19528519

Use of copper and insulin-resistance to accelerate cognitive deficits and synaptic protein loss in a rat Abeta-infusion Alzheimer's disease model. Begum AN, Yang F, Teng E, Hu S, Jones MR, Rosario ER, Beech W, Hudspeth B, Ubeda OJ, Cole GM, Frautschy SA. J Alzheimers Dis. 2008 Dec;15(4):625-40. PMID 19096161
Diagnosing depression in Alzheimer disease with the national institute of mental health provisional criteria. Teng E, Ringman JM, Ross LK, Mulnard RA, Dick MB, Bartzokis G, Davies HD, Galasko D, Hewett L, Mungas D, Reed BR, Schneider LS, Segal-Gidan F, Yaffe K, Cummings JL; Alzheimer's DiseaseResearch Centers of California-Depression in Alzheimer's Disease Investigators. Am J Geriatr Psychiatry. 2008 Jun;16(6):469-77. doi: 10.1097/JGP.0b013e318165dbae. PMID: 18515691

Neuropsychiatric symptoms are associated with progression from mild cognitive impairment toAlzheimer's disease. Teng E, Lu PH, Cummings JL. Dement Geriatr Cogn Disord. 2007;24(4):253-9. Epub 2007 Aug 14. PMID: 17700021

Deficits in facial emotion processing in mild cognitive impairment. Teng E, Lu PH, Cummings JL. Dement Geriatr Cogn Disord. 2007;23(4):271-9. Epub 2007 Mar 12. PMID: 17351319

Neuropsychological testing: helpful or harmful? Teng EL, Manly JJ. Alzheimer Dis Assoc Disord. 2005 Oct-Dec;19(4):267-71. PMID: 16327357

Cognitive reserve: a SPECT study of 132 Alzheimer's disease patients with an education range of 0-19 years.
Liao YC, Liu RS, Teng EL, Lee YC, Wang PN, Lin KN, Chung CP, Liu HC. Dement Geriatr Cogn Disord. 2005;20(1):8-14. Epub 2005 Apr 12. PMID:15832030

Cultural and educational factors in the diagnosis of dementia. Teng EL. Alzheimer Dis Assoc Disord. 2002;16 Suppl 2:S77-9. Review.   PMID:12351918

Performance on the cognitive abilities screening instrument at different stages of Alzheimer'sdisease. Liu HC, Teng EL, Lin KN, Chuang YY, Wang PN, Fuh JL, Liu CY. Dement Geriatr Cogn Disord. 2002;13(4):244-8.
PMID 12006735
The Alzheimer's Disease Assessment Scale: findings from a low-education population. Liu HC, Teng EL, Chuang YY, Lin KN, Fuh JL, Wang PN. Dement Geriatr Cogn Disord. 2002;13(1):21-6. PMID 11731711

Depressive disorders in Chinese patients with Alzheimer's disease. Liu CY, Fuh JL, Teng EL, Wang SJ, Wang PN, Yang YY, Liu HC. Acta Psychiatr Scand. 1999 Dec;100(6):451-5.PMID: 10626924
ApoE genotype in relation to AD and cholesterol: a study of 2,326 Chinese adults. Liu HC, Hong CJ, Wang SJ, Fuh JL, Wang PN, Shyu HY, Teng EL. Neurology. 1999 Sep 22;53(5):962-6. PMID: 10496253

Prevalence and subtypes of dementia in a rural Chinese population. Liu HC, Fuh JL, Wang SJ, Liu CY, Larson EB, Lin KN, Wang HC, Chou P, Wu ZA, Lin CH, Wang PN, Teng EL. Alzheimer Dis Assoc Disord. 1998 Sep;12(3):127-34.
PMID: 9772013

Prevalence of dementia in older Japanese-American men in Hawaii: The Honolulu-Asia Aging Study. White L, Petrovitch H, Ross GW, Masaki KH, Abbott RD, Teng EL, Rodriguez BL, Blanchette PL, Havlik RJ, Wergowske G, Chiu D, Foley DJ, Murdaugh C, Curb JD. JAMA. 1996 Sep 25;276(12):955-60. PMID: 8805729
Prevalence and subtypes of dementia in Taiwan: a community survey of 5297 individuals. Liu HC, Lin KN, Teng EL, Wang SJ, Fuh JL, Guo NW, Chou P, Hu HH, Chiang BN.
J Am Geriatr Soc. 1995 Feb;43(2):144-9. PMID: 7836638

Opportunities and challenges in international collaborative epidemiologic research of dementia and its subtypes: studies between Japan and the U.S. Graves AB, Larson EB, White LR, Teng EL, Homma A.
Int Psychogeriatr. 1994 Fall;6(2):209-23. PMID: 7865708

Temporal and hippocampal metabolic rate during an olfactory memory task assessed by positron emission tomography in patients with dementia of the Alzheimer type and controls. Preliminary studies. Buchsbaum MS, Kesslak JP, Lynch G, Chui H, Wu J, Sicotte N, Hazlett E, Teng E, Cotman CW. Arch Gen Psychiatry. 1991 Sep;48(9):840-7.PMID 1929775
Alzheimer's dementia: performance on parallel forms of the dementia assessment battery. Teng EL, Wimer C, Roberts E, Damasio AR, Eslinger PJ, Folstein MF, Tune LE, Whitehouse PJ, Bardolph EL, Chui HC, et al. J Clin Exp Neuropsychol. 1989 Dec;11(6):899-912. PMID:2687312

Multicenter trial of naloxone in Alzheimer's disease. Henderson VW, Roberts E, Wimer C, Bardolph EL, Chui HC, Damasio AR, Eslinger PJ, Folstein MF, Schneider LS, Teng EL, et al. Ann Neurol. 1989 Apr;25(4):404-6. PMID:2653175

The Modified Mini-Mental State (3MS) examination.Teng EL, Chui HC. J Clin Psychiatry. 1987 Aug;48(8):314-8. PMID:3611032

Alzheimer's dementia: performance on the Mini-Mental State Examination. Teng EL, Chui HC, Schneider LS, Metzger LE. J Consult Clin Psychol. 1987 Feb;55(1):96-100. No abstract available.PMID:3571664

Clinical subtypes of dementia of the Alzheimer type. Chui HC, Teng EL, Henderson VW, Moy AC. Neurology. 1985 Nov;35(11):1544-50.PMID:4058744

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