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Fusheng Yang, MD

Mary S. Easton Alzheimer's Translational Center

Senior Supervisor

UCLA Dept Neurology and GRECC/ Veterans GLA

 Fusheng Yang, MD

Fusheng Yang, M.D. is a Supervisor in our lab and the most senior member of our group since he joined Drs. Cole  Lab at UCSD in 1993 where he worked as a research fellow He runs several aspects of the lab including neurosurgery, managing and acquiring the brain inventory and running the confocal microscopy core.

In addition to publishing more than 45 manuscripts in our group, he has made several seminal contributions to the field.

*** A main acheivement in  Alzheimer’s study  was that  he contributed to development of the  1st academic Alzheimer transgenic mouse model in 1996 ( Drs. Karen Hsiao-Ashe mouse involving the collaborators Steven Younkin and Greg Cole (see Science 1996, 274:99). This article has been cited 3,000 times.

Another important contribution is my involvement in making and characterizing  an  antibody to detect  apoptosis events in Alzheimer’s disease. (“fractin” see AJP   1998, 152:379). The antibody is patented by University of California and transferred to  biotech companies for sale.

 

Fusheng was also the sention author on the original work identifying the mechansims of the dietary compound Curcumin in which I innovated several key techniques to answer the questions how curcumin effects A-beta oligmers and fibrils in vitro and in vivo, measured by ELISA,  Western Blot, Electronic Microscopy and immunohistochemistry. (see JBC, 2005, 280:5892).  The convincing results have led to initiation of UCLA medical center to promote curcumin clinical trials on Alzheimer’s patients. This article has been cited 888 times.

Prior to joining our group he was invited to work at  Greifswald University (Germany) at Ear-Nose-Throat Department, because of expertise in “A technique for temporal bone sections using non-decalcified frozen guinea pig cochleas, EuroArch of O-R-L, 1990, 247:283”

PUBLICATIONS

  1. Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice. Ma QL, Zuo X, Yang F, Ubeda OJ, Gant DJ, Alaverdyan M, Teng E, Hu S, Chen PP, Maiti P, Teter B, Cole GM, Frautschy SA. J Biol Chem. 2013 Feb 8;288(6):4056-65. doi: 10.1074/jbc.M112.393751. Epub 2012 Dec 21. PMID: 23264626 [PubMed - indexed for MEDLINE]
  2. PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. Ma QL, Yang F, Frautschy SA, Cole GM. Cell Logist. 2012 Apr 1;2(2):117-125. PMID: 23162743 [PubMed]
  3. [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment. Teng E, Kepe V, Frautschy SA, Liu J, Satyamurthy N, Yang F, Chen PP, Cole GB, Jones MR, Huang SC, Flood DG, Trusko SP, Small GW, Cole GM, Barrio JR. Neurobiol Dis. 2011 Sep;43(3):565-75. doi: 10.1016/j.nbd.2011.05.003. Epub 2011 May 13. PMID: 21605674
  4. Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM. J Neurosci. 2009 Jul 15;29(28):9078-89. doi: 10.1523/JNEUROSCI.1071-09.2009. PMID: 19605645
  5. Use of copper and insulin-resistance to accelerate cognitive deficits and synaptic protein loss in a rat Abeta-infusion Alzheimer's disease model. Begum AN, Yang F, Teng E, Hu S, Jones MR, Rosario ER, Beech W, Hudspeth B, Ubeda OJ, Cole GM, Frautschy SA. J Alzheimers Dis. 2008 Dec;15(4):625-40. PMID: 19096161
  6. GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals. Hu S, Begum AN, Jones MR, Oh MS, Beech WK, Beech BH, Yang F, Chen P, Ubeda OJ, Kim PC, Davies P, Ma Q, Cole GM, Frautschy SA. Neurobiol Dis. 2009 Feb;33(2):193-206. doi: 10.1016/j.nbd.2008.10.007. Epub 2008 Nov 5. PMID: 19038340
  7. Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH. Am J Pathol. 2008 Jun;172(6):1683-92. doi: 10.2353/ajpath.2008.070829. Epub 2008 May 8. PMID: 18467692
  8. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA. J Pharmacol Exp Ther. 2008 Jul;326(1):196-208. doi: 10.1124/jpet.108.137455. Epub 2008 Apr 16. PMID: 18417733
  9. p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis. Ma QL, Yang F, Calon F, Ubeda OJ, Hansen JE, Weisbart RH, Beech W, Frautschy SA, Cole GM. J Biol Chem. 2008 May 16;283(20):14132-43. doi: 10.1074/jbc.M708034200. Epub 2008 Mar 17. PMID: 18347024
  10. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM. Nat Neurosci. 2006 Feb;9(2):234-42. Epub 2006 Jan 15. PMID: 16415866
  11. Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe CG, Teter B, Frautschy SA, Cole GM. J Neurosci Res. 2006 Feb 15;83(3):374-84. PMID: 16385556
  12. Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex. Gylys KH, Fein JA, Yang F, Miller CA, Cole GM. Neurobiol Aging. 2007 Jan;28(1):8-17. Epub 2005 Dec 5. PMID: 16332401
  13. Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions. Cole GM, Lim GP, Yang F, Teter B, Begum A, Ma Q, Harris-White ME, Frautschy SA. Neurobiol Aging. 2005 Dec;26 Suppl 1:133-6. Epub 2005 Nov 2. Review. PMID: 16266772
  14. Calon F, Lim GP, Morihara T, Yang F, Ubeda O, Salem N Jr, Frautschy SA, Cole GM.   Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. Eur J Neurosci. 2005 Aug;22(3):617-26. PMID: 16101743 [PubMed - in process]
  15. Lim GP, Calon F, Morihara T, Yang F, Teter B, Ubeda O, Salem N Jr, Frautschy SA, Cole GM.  A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci. 2005 Mar 23;25(12):3032-40. PMID: 15788759 [PubMed - in process]
  16. Morihara T, Teter B, Yang F, Lim GP, Boudinot S, Boudinot FD, Frautschy SA, Cole GM. Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models. Neuropsychopharmacology. 2005 Jun;30(6):1111-20. PMID: 15688088 [PubMed - indexed for MEDLINE]
  17. Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA.  NSAID and Antioxidant Prevention of Alzheimer's Disease: Lessons from In Vitro and Animal Models. Ann N Y Acad Sci. 2004 Dec;1035:68-84. PMID: 15681801 [PubMed - in process]
  18. Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18;280(7):5892-901. Epub 2004 Dec 7. PMID: 15590663 [PubMed - indexed for MEDLINE]
  19. Weisbart RH, Hansen JE, Chan G, Wakelin R, Chang SS, Heinze E, Miller CW, Koeffler PH, Yang F, Cole GM, Min YS, Nishimura RN. Antibody-mediated transduction of p53 selectively kills cancer cells. Int J Oncol. 2004 Dec;25(6):1867-73.PMID: 15547728 [PubMed - indexed for MEDLINE]
  20. Gylys KH, Fein JA, Yang F, Wiley DJ, Miller CA, Cole GM. Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol. 2004 Nov;165(5):1809-17. PMID: 15509549 [PubMed - indexed for MEDLINE]
  21. Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N Jr, Ashe KH, Frautschy SA, Cole GM. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron. 2004 Sep 2;43(5):633-45. PMID: 15339646 [PubMed - indexed for MEDLINE]
  22. Gylys KH, Fein JA, Yang F, Cole GM.  Enrichment of presynaptic and postsynaptic markers by size-based gating analysis of synaptosome preparations from rat and human cortex.Cytometry A. 2004 Jul;60(1):90-6. PMID: 15229861 [PubMed - indexed for MEDLINE]
  23. Weisbart RH, Yang F, Chan G, Wakelin R, Ferreri K, Zack DJ, Harrison B, Leinwand LA, Cole GM.  Cell type specific targeted intracellular delivery into muscle of a monoclonal antibody that binds myosin IIb. Mol Immunol. 2003 Mar;39(13):783-9. PMID: 12617993 [PubMed - indexed for MEDLINE]
  24. Tomioka M, Shirotani K, Iwata N, Lee HJ, Yang F, Cole GM, Seyama Y, Saido TC.  In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons. Brain Res Mol Brain Res. 2002 Dec;108(1-2):18-32. PMID: 12480175 [PubMed - indexed for MEDLINE]
  25. Rossiter JP, Anderson LL, Yang F, Cole GM. Caspase-3 activation and caspase-like proteolytic activity in human perinatal hypoxic-ischemic brain injury. Acta Neuropathol (Berl). 2002 Jan;103(1):66-73. PMID: 11841033 [PubMed - indexed for MEDLINE]
  26. Lim GP, Yang F, Chu T, Gahtan E, Ubeda O, Beech W, Overmier JB, Hsiao-Ashec K, Frautschy SA, Cole GM. Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging. 2001 Nov-Dec;22(6):983-91. PMID: 11755007 [PubMed - indexed for MEDLINE]
  27. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 1;21(21):8370-7. PMID: 11606625 [PubMed - indexed for MEDLINE]
  28. Chen TA, Yang F, Cole GM, Chan SO.  Inhibition of caspase-3-like activity reduces glutamate induced cell death in adult rat retina. Brain Res. 2001 Jun 15;904(1):177-88. PMID: 11516428 [PubMed - indexed for MEDLINE]
  29. Adamec E, Yang F, Cole GM, Nixon RA.     Multiple-label immunocytochemistry for the evaluation of nature of cell death in experimental models of neurodegeneration. Brain Res Brain Res Protoc. 2001 Jul;7(3):193-202. PMID: 11431120 [PubMed - indexed for MEDLINE]
  30. Rossiter JP, Anderson LL, Yang F, Cole GM.       Caspase-cleaved actin (fractin) immunolabelling of Hirano bodies. Neuropathol Appl Neurobiol. 2000 Aug;26(4):342-6. PMID: 10931367 [PubMed - indexed for MEDLINE]
  31. Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA, Cole GM.        Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.J Neurosci. 2000 Aug 1;20(15):5709-14. PMID: 10908610 [PubMed - indexed for MEDLINE]
  32. Horsburgh K, Cole GM, Yang F, Savage MJ, Greenberg BD, Gentleman SM, Graham DI, Nicoll JA.       beta-amyloid (Abeta)42(43), abeta42, abeta40 and apoE immunostaining of plaques in fatal head injury. Neuropathol Appl Neurobiol. 2000 Apr;26(2):124-32. PMID: 10840275 [PubMed - indexed for MEDLINE]
  33. McCarron MO, Nicoll JA, Stewart J, Cole GM, Yang F, Ironside JW, Mann DM, Love S, Graham DI. Amyloid beta-protein length and cerebral amyloid angiopathy-related haemorrhage. Neuroreport. 2000 Apr 7;11(5):937-40. PMID: 10790859 [PubMed - indexed for MEDLINE]
  34. Yang F, Ueda K, Chen P, Ashe KH, Cole GM.     Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein. Brain Res. 2000 Jan 24;853(2):381-3. PMID: 10640638 [PubMed - indexed for MEDLINE]
  35. Suurmeijer AJ, van der Wijk J, van Veldhuisen DJ, Yang F, Cole GM.    Fractin immunostaining for the detection of apoptotic cells and apoptotic bodies in formalin-fixed and paraffin-embedded tissue.Lab Invest. 1999 May;79(5):619-20.   PMID: 10334574 [PubMed - indexed for MEDLINE]
  36. Pulera MR, Adams LM, Liu H, Santos DG, Nishimura RN, Yang F, Cole GM, Wasterlain CG. Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia. Stroke. 1998 Dec;29(12):2622-30.PMID: 9836776 [PubMed - indexed for MEDLINE]
  37. Chu T, Tran T, Yang F, Beech W, Cole GM, Frautschy SA. Effect of chloroquine and leupeptin on intracellular accumulation of amyloid-beta (A beta) 1-42 peptide in a murine N9 microglial cell line.FEBS Lett. 1998 Oct 9;436(3):439-44. PMID: 9801165 [PubMed - indexed for MEDLINE]
  38. Frautschy SA, Horn DL, Sigel JJ, Harris-White ME, Mendoza JJ, Yang F, Saido TC, Cole GM.   Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain. J Neurosci. 1998 Oct 15;18(20):8311-21. PMID: 9763475 [PubMed - indexed for MEDLINE]
  39. Yang F, Sun X, Beech W, Teter B, Wu S, Sigel J, Vinters HV, Frautschy SA, Cole GM.  Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am J Pathol. 1998 Feb;152(2):379-89. PMID: 9466564 [PubMed - indexed for MEDLINE]
  40. Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM.  Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol. 1998 Jan;152(1):307-17. PMID: 9422548 [PubMed - indexed for MEDLINE]
  41. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G.  Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 1996 Oct 4;274(5284):99-102. PMID: 8810256 [PubMed - indexed for MEDLINE]
  42. Frautschy SA, Yang F, Calderon L, Cole GM.     Rodent models of Alzheimer's disease: rat A beta infusion approaches to amyloid deposits. Neurobiol Aging. 1996 Mar-Apr;17(2):311-21. PMID: 8744413 [PubMed - indexed for MEDLINE]
  43. Tekirian TL, Cole GM, Russell MJ, Yang F, Wekstein DR, Patel E, Snowdon DA, Markesbery WR, Geddes JW.  Carboxy terminal of beta-amyloid deposits in aged human, canine, and polar bear brains. Neurobiol Aging. 1996 Mar-Apr;17(2):249-57. PMID: 8744406 [PubMed - indexed for MEDLINE]
  44. Mak K, Yang F, Vinters HV, Frautschy SA, Cole GM Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum. Brain Res. 1994 Dec 19;667(1):138-42. PMID: 7895077 [PubMed - indexed for MEDLINE]
  45. Yang F, Mak K, Vinters HV, Frautschy SA, Cole GM.  Monoclonal antibody to the C-terminus of beta-amyloid.Neuroreport. 1994 Oct 27;5(16):2117-20.PMID: 7865758 [PubMed - indexed for MEDLINE

My hobbies are to explore  nature and photography.

 Death Valley, 04/2005

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