Alzheimer

Research Lab

Post Doctoral Scholar

now at USC w/Christian Pike

 Emily Rosario ., Ph.D. erosario@ucla.edu

Dr. Rosario worked in our lab industriously for one year starting March 2007. After completing her PHD at USC in 2006, she joined our lab. She also received a Masters of Science, in Biological Sciences   (2000-2002) from Eastern Illinois University and a Bachelor of Science, Biology   (1996-2000) from Kansas State University.

She has received many awards including an    Heinz Osterberg Dissertation Prize at the Davis School of Gerontology, USC, a NRSA predoctoral grant (1F31NS05214301A1)     as well as a        Multidisciplinary Research Training in Gerontology Grant , a Neuroscience Provost Fellowship , and an award for Outstanding Graduate Student  at Eastern Illinois University. In her short time spent at our Alzheimer lab at UCLA/VA, she has supervised several different dietary and behavioral projects on different Alzheimer's transgenics and also ran samples from an Alzheimer's clinical trial on the LUMINEX in addition to keeping the transgenic colony in order.

Publications:

• Rosario, E.R., Struble, R.G., Kircher, M., McAdamis, P., Nathan, B.P. (2003) Effects of 17b-estradiol in ApoE modulation in mouse brain. Experimental Neurology183: 638-644.

• Rosario, E.R., Chang, L., Stanczyk, F.Z., Pike, C.J.  (2004) Age-related testosterone depletion and the development of Alzheimer’s disease.  JAMA 292: 1431-1432.

• Pike, C.J., Rosario E.R., Nguyen T.V. (2006) Androgens, Aging, and Alzheimer’s Disease. Endocrine 29: 233-242.

• Rosario, E.R., Ramsden. M., Pike, C.J. (2006) Progestins inhibit the neuroprotective effects of estrogen in rat hippocampus. Brain Research 1099(1):206-10.

• Rosario, E.R., Carroll, J.C., Chang, L., Stanczyk, F.Z., Oddo, S., LaFerla, F., Pike, C.J. (2007) Androgens regulate development of neuropathology in a triple transgenic mouse model of Alzheimer’s disease.  Journal of Neuroscience 26 (51): 13384-9.

• Carroll, J.C., Rosario, E.R., Chang, L., Stanczyk, F., Oddo, S., LaFerla, F., Pike, C.J. Progesterone blocks estrogen-mediated inhibition of Ab accumulation in female 3xTg-AD mice.  Journal of Neuroscience 27 (48): 13357-65.

• Rosario, E.R., and Pike, C.J. (2007) Androgen regulation of b-amyloid protein and the risk of Alzheimer’s disease. Brain Research Review In press (epub July 7).

• Pike, C.J., Nguyen, T.V., Ramsden, M., Yao, MZ., Murphy, M.P., Rosario, E.R. Androgen cell signaling pathways involved in neuroprotective actions. Hormones and Behavior In press.

• Ringman, J.M., Younkin, S.G., Pratico, .D., Seltzer, W., Cole, G.M., Geschwind, D.H., Rodriguez, Y., Schaffer, B., Fein, J., Sokolow, S., Rosario, E.R., Gylys, K.H., Varpetian, A., Medina, L.D., Cummings, J.L.Biochemical Markers in Persons with Pre-Clinical Familial Alzheimer's Disease. NeurologyIn press.

• Rosario, E.R., Chang, L., Head, E., Stanczyk, F.Z., Pike C.J.  Age-related changes in brain levels of sex steroid hormone in women and men and their relationship to Alzheimer’s disease.  Manuscript in preparation

• Rosario, E.R., Carroll, J.C., Murphy, M.P., Chang, L., Stanczyk, F.Z., Pike, C.J. Age-related testosterone decline and increased Ab in brown Norway rat brain. Manuscript in preparation

• Rosario, E.R., Carroll, J.C., Pike, C.J. Androgen regulation of Alzheimer-like neuropathology in male 3XTg-AD mice is through androgen and estrogen mediated pathways. Manuscript in preparation

• Rosario, E.R., Carroll, J.C., Pike, C.J. Androgens and Gonadotropins in regulation of Alzheimer-like neuropathology in male 3XTg-AD mice. Manuscript in preparation

• Carroll, J.C., Rosario, E.R., McMullan, K., Pike, C.J..  Progesterone blocks estrogen-induced neuroprotection against kainate lesion in reproductively senescent female rodents.  Manuscript in preparation

• Ramsden, M., Rosario, E.R., Quaglino, A.E., Cordey, M., Shin, T.M., Pike, C.J.  Differential neuroprotection by sex steroid hormones in male and female rat hippocampus.  Manuscript in preparation

Abstracts:

• Nathan, B.P., Ludwig, S., Rosario, E., Jesse Stuckey, Paul McAdamis, R.G.
  Struble.  Effects Of Estrogen On Olfactory Bulb Following Olfactory Nerve
  Lesioning In Mice. Soc. Neurosci. Abstr. Vol. 27, 2001.

• Rosario, E.R., Struble, R.G., Kircher, M., McAdamis, P., Nathan, B.P. Effects of 17b-estradiol in ApoE modulation in mouse brain. Soc. Neurosci Abstr. (2002) – poster presentation 

• Rosario, E.R., Chang, L., Stanczyk, F.Z., Pike, C.J.  Analysis of sex steroid hormones levels in male brain in both normal aging and AD. Soc. Neurosci Abstr. (2003) - poster presentation

• Ramsden, M., Rosario, E.R., Quaglino, A.E., Cordey, M., Shin, T.M., Pike, C.J.  Estrogen and androgen neuroprotection against kainite lesion in male and female rats. Soc. Neurosci Abstr. (2003) - poster presentation.

• Ramsden, M., Rosario, E.R., Nyborg, A., Chang, L., Murphy, P., Stanczyk, F.Z., Golde, T.E., Pike, C.J.  Regulation of b-amyloid levels by estrogen and progesterone  Soc Neurosci Abstr. (2004) - poster presentation

• Rosario, E.R., Chang, L., Stanczyk, F.Z., Pike, C.J Age-related testosterone depletion in brain increases the risk of Alzheimer's disease.  Soc Neurosci Abstr (2004) - oral presentation

• Rosario, E.R., Murphy, L. Chang, F.Z. Stanczyk, C.J. Pike.   Role of sex steroid hormone receptors in estrogen and androgen mediated regulation of beta-amyloid levels.  Soc Neurosci Abstr (2005) - poster presentation

• Rosario, E.R., Carroll, J., Chang, L., Stanczyk, F.Z., Oddo, S., LaFerla, F., Pike, C.J.  Androgens regulate development of neuropathology in a triple transgenic mouse model of Alzheimer’s disease. International Conference for Alzheimer’s disease (2006) - poster presentation

• Rosario, E.R., Carroll, J.C., Oddo, S., LaFerla, F.M., Pike, C.J.Androgen depletion accelerates development of neuropathology in a triple transgenic mouse model of AD.  Soc Neurosci Abstr (2006) - oral presentation