Dr. Maiti worked in our laboratory from 2011-2012. During that time he did extensive work on heat shock proteins and their interactions with curcumin and celastrol. He has published several manuscripts on APP processing and Alzheimer's related mechanisms. He received his Ph.D. Physiology (Neuroscience) in 2007 from the DRDO/Bharathiar University, Coimbatore, India in the study the mechanism of memory impairment at high altitude in animal model. and a M.Sc. Human Physiology with Community Health, 2002, Vidyasagar University, Midnapur, West Bengal, India studying Role of Andrographis paniculata on DNA, RNA and protein content of hepatocytes of ethanol exposed mice. He received his, B.Sc. Physiology (Honors), 1999, Vidyasagar University, West Bengal, India and a Postgraduate Diploma in Laboratory Technology (PGDLT), 2000, School of Tropical Medicine, Kolkota, West Bengal, India

From 2008-2011 He was Postdoctoral Research Fellow, Dept of Neurology, University of California at Los Angeles, in Dr. Gal Bitan's Lab. From 2004-2007, Research Fellow, Neurobiology Division, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Ministry of Defence, Delhi, India. • 2003-2004, Research Assistant, Dept. of Biotechnology, Indian Institute of Technology, Kharagpur, Dept of Human Physiology with Community Health, Vidyasagar University, West Bengal, India. Research projects/experience Postdoctoral (2008-till date)

His focus of study is the structure function relationship of amyloid-β protein in Alzheimer’s disease • :

Honors /Awards

1. University gold medal, 2002

2. Endowment award, 2002

3. DRDO Research Fellowship 2004-2007

4. IBRO travel award 2007, 7thWorld Neuroscience Congress, Melbourne, Australia

5. Travel award of Neuro 2007, Japanese Neuroscience Society, Yokohama, Japan

6. Surgeon. Rear Admiral M.S. Malhotra Research prize, 2007, DRDO, Delhi, India

7. Prof. P.B. Sen. Memorial Research Prize (Young Scientist Award for best paper published) in XIXth Annual conference of Physiological Society of India, 2007

8. Travel Award of International Conference on Alzheimer’s Disease (ICAD), Honolulu, Hawaii, July, 2010.

Memberships

1. Society For Neuroscience (SFN)

2. International Brain Research Organization (IBRO)

3. Japanese Neuroscience Society (JNS)

4. Indian academy of Neuroscience (IAN)

5. Association of Physiologist and Pharmacologist of India (APPI)

6. Physiological Society of India (PSI)

7. Indian Association of Biomedical Scientist (IABMS)

Publications

1. Maiti P, Lomakin A, Benedek G.B, Bitan G. Methionine 35 is not necessary for Amyloid beta protein toxicity. J. Neuro Chem. 2010; (In Press).

2. Sinha S, Attar A, Maiti P, Pang E, et al. Rational, Structure-based small molecule inhibitors of amyloid β-protein assembly and toxicity. Nat. Lett. 2009; (under 2nd review).

3. Maiti P, Moskovitz J, Piacentini R, Ripoli C, Claudio Grassi C, and Bitan G. Mechanistic insight into the consequences amyloid β-protein oxidation. Neurobiol of Aging. 2010, (submitted).

4. Li H, Rahimi F, Sinha S, Maiti P, Murakami K, and Bitan G. Amyloids and Protein Aggregation-analytical methods. 2009; Encyclopedia in Anal. Chem.

5. Muthuraju S, Maiti P, Solanki P, Sharma AK, Singh SB, Ilavazhagan G. Hypoxia induced spatial learning deficits in rats; role of cholinesterase inhibitors. Expt. Brain Res. 2010; (In press).

6. Muthuraju S, Maiti P, Solanki P, Sharma AK, Singh SB, Ilavazhagan G. Role of cholinergic markers on memory function of rats exposed to hypobaric hypoxia. Europ. J. of Pharmacology. 2009; (under 2nd review).

7. Muthuraju S, Maiti P, Solanki P, Sharma AK, Amitabh, Singh SB, Prasad D, Ilavazhagan G. Acetylcholine esterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. Behav. Brain Res. 2009; 12;203(1):1-14.

8. Rahimi F, Maiti P, Bitan G. Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides. J. Vis Exp. 2009; 12;(23), 1071.

9. Maiti P, Singh SB, Ilavazhagan G. Nitric oxide system is involved in hypobaric hypoxia induced oxidative stress in rat brain. Acta Histochem. 2009, 112(3):222-32.

10. Maiti P, Singh SB, Mallick B, Muthuraju S, Ilavazhagan G. High altitude memory impairment is due to neuronal apoptosis in hippocampus, cortex and striatum. J. Chem. Neuroanat. 2008; 36(3-4): 227-38.

11. Maiti P, Muthuraju S, Ilavazhagan G, Singh SB. Hypobaric hypoxia induces dendritic plasticity in cortical and hippocampal pyramidal neurons in rat brain. Behav. Brain Res. 2008; 189(2): 233-43.

12. Maiti P, Singh SB, Muthuraju S, and Ilavazhagan G. Hypobaric hypoxia induces neuronal damage leading to special memory impairment in rat. Neurosci Res, 2007; P3-g23.

13. Muthuraju S, Singh SB, Maiti P, Amitabh, Ilavazhagan G. Physostigmine mitigates working memory loss during hypobaric hypoxia through cholinergic system. Neuropathlogy. 2007; O-I-A07, 162.

14. Maiti P, Singh SB, Muthuraju S, Veleri S, Ilavazhagan G. Hypobaric hypoxia damages the hippocampal pyramidal neurons in the rat brain. Brain Res. 2007; 1175:1-9.

15. Maiti P, Singh SB, Sharma AK, Muthuraju S, Banerjee PK, Ilavazhagan G. Hypobaric hypoxia induces oxidative stress in rat brain. Neurochem Int. 2006; 49(8):709-16.

16. Maiti P, Maiti T, Maiti P, Roy S. Smoking induced oxidative burst of neurotrophil and related alteration and damage of serum lipids. V.U. J. Biol. Sci. 2002, 8: 70-78. Patent Gal Bitan, Panchanan Maiti, Jackob Moskovitz. Protection Against Oxidative Stress by Activators of Methionine Sulfoxide Reductase. 2010 (UCLA Case No. 2010-652, submitted).

Papers presented in international conferences

1. Maiti P, Moskovitz J, Piacentini R, Ripoli C, Lomakin A, Grassi C, Benedek GB, and Bitan G. Aβ sulfoxide but not Aβ-sulfone reduces neurotoxicity through the methionine sulfoxide reductase system. International Conference in Alzheimer’s Disease, Hawaii, July, 2010.

2. Maiti P, Lomakin A, Benedek GB, and Bitan G. Is methionine 35 really necessary for amyloid β-protein toxicity? International Conference in Alzheimer’s Disease, Hawaii, July, 2010.

3. Bitan G, Sinha S, Attar A, Maiti P, Tan M, Prabhudesai S, Talbiersky P, Bakshi R, Kuo PY, Yang F, Jones MR, Xie CW, Bronstein J, Frautschy SA, Klärner FG, Schrader T. Novel, small molecule inhibitors of protein aggregation for treatment of amyloid-related diseases. International Conference in Alzheimer’s Disease, Hawaii, July, 2010.

4. Maiti P, Piacentini R, Ripoli C, Grassi C, Moskovitz J and Bitan G. Is methionine sulfoxide reductase the reason for the lower toxicity of oxidized versus reduced Aβ? Society for Neuroscience, Chicago, Oct, 2009.

5. Attar A, Sinha S, Maiti P, Yang F, Hu S, Gant D, Talbiersky P, Clamer FG, Frautschy S, and Bitan G. Rationally identified small molecules inhibit amyloid beta-protein assembly and toxicity by a novel mechanism. Society for Neuroscience, Chicago, Oct, 2009.

6. Sinha S, Attar A, Kuo PY, Bakshi R, Maiti P, Talbiersky P, Lomakin A, Tan M, Pang E, Du Z, Yang F, Hu S, Gant D, Jones M, Wang C, Loo J, Frautschy S, Xie CW, Benedek G, Schrader T, Bitan G. Rationally identified small molecules inhibit amyloid beta-protein assembly and toxicity by a novel mechanism. Protein Society, Boston, Aug, 2009.

7. Ripoli C, Piacentini R, Leoni G, Maiti P, Azzena GA, Bitan G and Grassi C. Amyloid-beta peptide (Abeta)-induced dysregulation of intracellular Ca2+ signalling in rat neocortical neurons depends upon the chemical state of methionine 35. Cell Death and Degeneration Conference, May 2009, Rome, Italy.

8. Maiti P, Singh SB, Muthuraju S and Ilavazhagan G. Hypobaric hypoxia induces neuronal damage leading to special memory impairment in rat. Neuro 2007, Yokohama, Japan, Sept. 2007.

9. Maiti P, Singh SB, Muthuraju S, Ilavazgagan G. Hypobaric hypoxia induces apoptosis leads to spatial memory impairment in rat. 7Th IBRO World Neuroscience Congress, Melbourne, Australia, July 2007.

10. Muthuraju S, Singh SB, Maiti P, Amitabh, Ilavazhagan G. Physostigmine mitigates working memory loss during hypobaric hypoxia through cholinergic system. Conference in Japanese Society of Neuropathology, Tokyo, Japan, pp-162, May 2007.

11. Singh SB, Jaylakshmi K, Kalpana B, Maiti. P, Muturaju S, Banerjee PK, Ilavaghazan G. Protective role of antioxidants in preventing impairment of spatial memory in rats following exposure to hypobaric hypoxia. Conference of Neuroscience, USA, May 2005.

Papers presented in national conferences

1. Maiti P, Singh SB, Muthuraju S, Ilavazaghan G. Neuronal damage in hippocampus, cortex and striatum are associated with high altitude memory impairment. 19th Annual conference, Physiological Society of India, Dec 6-8th, 2007.

2. Muthuraju S, Maiti P, Singh SB, Sharma AK, Ilavazhagan G. Galantamine improves spatial working memory of rats following hypobaric hypoxia. 28th Annual conference of IABMS. 2007. (Abstract OP-42, pp-107).

3. Maiti P, Singh SB, Muthuraju S, Sharma AK, Ilavaghazan G. Hypobaric hypoxia induces dendritic plasticity of prefrontalcortex and hippocapal pyramidal neurons in rat brain. 24th Annual conference of Indian Academy of Neuroscience, Nov 2007.

4. Panchanan Maiti, Shashi B. Singh, S. Muthuraju, G. Ilavazhagan. Hippocampal damage in chronic hypobaric hypoxia is duration dependent. 4th Conference of Federation of Indian Physiological Societies, Jan 2007.

5. Maiti P, Singh SB, Muthuraju S, Ilavazhagan G, Banerjee PK. Hypobaric hypoxia: cortex is more vulnerable to damage than the striatum. 3rd NBRC International Conference, Dec 2006.

6. Maiti P, Singh SB, Muthuraju S, Ilavazhagan G, Banerjee PK. Hypobaric hypoxia damages the cortex, hippocampus and striatum of rat brain. Indian Academy of Neurosciences, Dec 2006.

7. Maiti P, Singh SB, Muthuraju S, Ilavazhagan G, Banerjee PK. Hypobaric hypoxia damages hippocampal pyramidal neurons in rat brain. Indian Association of Biomedical Scientist, Nov. 2005.

8. Maiti P, Singh SB, Muthuraju S, Ilavazhagan G, Banerjee PK. Hypobaric hypoxia induces neuronal damage in rat brain. Indian Academy of Neurosciences, Dec 2005.

9. Maiti P, Jayalakshmi K, Sharma AK, Singh SB, Ilavaghazan G, Banerjee PK. Oxidative stress markers in rat brain after exposure to hypobaric hypoxia. Indian Association of Biomedical Scientist, Oct. 2004. Journals responsibility as reviewer European. Journal of Pharmacology, Neuropsychology, Current Proteomics (Adhoc), Disease Markers (Adhoc).

Conferences attended

1. 39th Annual meeting: Society for Neuroscience, 2009, Oral presentation

2. 38th Annual meeting: Society for Neuroscience, 2008, Deligate

3. 25th Annual conference: Indian Academy of Neuroscience, 2007, Oral presentation

4. XIXth Annual conference: Physiological Society of India, 2007, Oral presentation

5. 4th Conference: Federation of Indian Physiological Societies, 2007, Poster

6. 3rd international conference: National Brain Research Center, 2006, Poster

7. XIV Annual conference: Indian Academy of Neuroscience, 2006, Oral presentation

8. XXIII Annual Meeting: Indian Academy of Neuroscience, 2005, Poster

9. XXVI Annual conference: Indian Association of Biomedical Scientist, 2005, Poster

10. XXV annual conference: Indian Association of Biomedical Scientist, 2004, Poster

11. Golden APPICON: Association of Physiologist and Pharmacologist of India, 2004, Deligate.

Workshops/Symposia attended

1. Workshop on stereo logy: Dept of Anatomy, All India Institute of Medical Sciences, Delhi, 2007.

2. Imaging and manipulation of neuron and glia: RIKEN/APRC IBRO Advanced School. RIKEN Brain Science Institute, Japan, 2007.

3. Neuronal plasticity in brain & neuronal plasticity in pain: All India Institute of Medical sciences, Delhi, DST sponsored, 2006.

4. 8th IBRO school of Neuroscience: Tata Institute of Fundamental Research, Mumbai, International Brain Research Organization sponsored, 2006.

5. Frontier of cellular imaging in neurobiology: Imaging structure and function of nervous system, National Institute of Mental Health And Neuroscience, Bangalore, Department of Science and Technology sponsored, 2005.

6. Modern techniques in neuroscience Research: SN Pradhan Centre for Neuroscience, Kolkata, Indian Association of Bio-Medical Scientist sponsored, 2005.

7. Pathology of neurodegenerative Diseases: National Institute of Mental Health And Neuroscience, Bangalore, Medical council of India sponsored, 2004.

8. Brain and Behavior: National Institute of Mental Health And Neuroscience, Bangalore, DST sponsored, 2004.