Significant publications from the Mary S. Easton Translational Research Center

  1. Ma QL, Zuo X, Yang F, Ubeda OJ, Gant DJ, Alaverdyan M, Teng E, Hu S, Chen PP,  Maiti P, Teter B, Cole GM, Frautschy SA. Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged humantau transgenic mice. J Biol Chem. 2013 Feb 8;288(6):4056-65. doi: 10.1074/jbc.M112.393751. Epub 2012 Dec 21. PubMed PMID: 23264626; PubMed Central  PMCID: PMC3567657. 

      2: Attar A, Ripoli C, Riccardi E, Maiti P, Li Puma DD, Liu T, Hayes J, Jones MR,  Lichti-Kaiser K, Yang F, Gale GD, Tseng CH, Tan M, Xie CW, Straudinger JL, Klarner FG, Schrader T, Frautschy SA, Grassi C, Bitan G. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012 Dec;135(Pt 12):3735-48. doi: 10.1093/brain/aws289. Epub 2012 Nov 26. PubMed  PMID: 23183235; PubMed Central PMCID: PMC3525056. 

      3: Ma QL, Yang F, Frautschy SA, Cole GM. PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. Cell Logist. 2012 Apr 1;2(2):117-125. PubMed PMID: 23162743; PubMed Central PMCID: PMC3490962. 

      4: Roychaudhuri R, Yang M, Deshpande A, Cole GM, Frautschy S, Lomakin A, Benedek  GB, Teplow DB. C-terminal turn stability determines assembly differences between  Abeta40 and Abeta42. J Mol Biol. 2013 Jan 23;425(2):292-308. doi: 10.1016/j.jmb.2012.11.006. Epub 2012 Nov 12. PubMed PMID: 23154165; PubMed Central PMCID: PMC3540122. 

      5: Ringman JM, Frautschy SA, Teng E, Begum AN, Bardens J, Beigi M, Gylys KH, Badmaev V, Heath DD, Apostolova LG, Porter V, Vanek Z, Marshall GA, Hellemann G,  Sugar C, Masterman DL, Montine TJ, Cummings JL, Cole GM. Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimers Res Ther. 2012 Oct 29;4(5):43. [Epub  ahead of print] PubMed PMID: 23107780; PubMed Central PMCID: PMC3580400. 

      6: Ringman JM, Elashoff D, Geschwind DH, Welsh BT, Gylys KH, Lee C, Cummings JL,  Cole GM. Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype. Arch Neurol. 2012 Jun;69(6):757-64. doi: 10.1001/archneurol.2012.277. PubMed PMID: 22689192. 

      7: Hickey MA, Zhu C, Medvedeva V, Lerner RP, Patassini S, Franich NR, Maiti P, Frautschy SA, Zeitlin S, Levine MS, Chesselet MF. Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease. Mol Neurodegener. 2012 Apr 4;7:12. doi: 10.1186/1750-1326-7-12. PubMed PMID: 22475209; PubMed Central PMCID: PMC3348060. 

      8: Ringman JM, Coppola G, Elashoff D, Rodriguez-Agudelo Y, Medina LD, Gylys K, Cummings JL, Cole GM. Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease. Dement Geriatr Cogn Disord. 2012;33(1):1-5. doi: 10.1159/000335729. Epub 2012 Feb 13. PubMed PMID: 22343824. 

      9: Ringman JM, Schulman H, Becker C, Jones T, Bai Y, Immermann F, Cole G, Sokolow S, Gylys K, Geschwind DH, Cummings JL, Wan HI. Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease  mutations. Arch Neurol. 2012 Jan;69(1):96-104. doi: 10.1001/archneurol.2011.642.  PubMed PMID: 22232349; PubMed Central PMCID: PMC3632731. 

      10: Sokolow S, Henkins KM, Williams IA, Vinters HV, Schmid I, Cole GM, Gylys KH.  Isolation of synaptic terminals from Alzheimer's disease cortex. Cytometry A. 2012 Mar;81(3):248-54. doi: 10.1002/cyto.a.22009. Epub 2011 Dec 28. PubMed PMID:  22213704; PubMed Central PMCID: PMC3315390. 

      11: Borbon IA, Hillman Z, Duran E Jr, Kiela PR, Frautschy SA, Erickson RP. Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1. Pharmacol Biochem Behav. 2012 Mar;101(1):125-31. doi: 10.1016/j.pbb.2011.12.009. Epub 2011 Dec 17. PubMed PMID: 22202649; PubMed Central PMCID: PMC3466425. 

      12: Arold S, Sullivan P, Bilousova T, Teng E, Miller CA, Poon WW, Vinters HV, Cornwell LB, Saing T, Cole GM, Gylys KH. Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. Acta Neuropathol. 2012 Jan;123(1):39-52. doi: 10.1007/s00401-011-0892-1. Epub 2011 Oct 22. PubMed PMID: 22020632; PubMed Central PMCID: PMC3404604. 

      13: Sokolow S, Henkins KM, Bilousova T, Miller CA, Vinters HV, Poon W, Cole GM, Gylys KH. AD synapses contain abundant ABETA monomer and multiple soluble oligomers, including a 56-kDa assembly. Neurobiol Aging. 2012 Aug;33(8):1545-55. doi: 10.1016/j.neurobiolaging.2011.05.011. Epub 2011 Jul 7. PubMed PMID: 21741125; PubMed Central PMCID: PMC3193864. 

      14: Teng E, Kepe V, Frautschy SA, Liu J, Satyamurthy N, Yang F, Chen PP, Cole GB, Jones MR, Huang SC, Flood DG, Trusko SP, Small GW, Cole GM, Barrio JR. [F-18]FDDNP microPET imaging correlates with brain ABETA burden in a transgenic rat  model of Alzheimer disease: effects of aging, in vivo blockade, and anti-ABETA antibody treatment. Neurobiol Dis. 2011 Sep;43(3):565-75. doi: 10.1016/j.nbd.2011.05.003. Epub 2011 May 13. PubMed PMID: 21605674; PubMed Central PMCID: PMC3144750. 

      15: Frautschy SA, Cole GM. What was lost in translation in the DHA trial is whom  you should intend to treat. Alzheimers Res Ther. 2011 Jan 20;3(1):2. doi: 10.1186/alzrt61. PubMed PMID: 21251328; PubMed Central PMCID: PMC3109411. 

      16: Cole GM, Ma QL, Frautschy SA. Dietary fatty acids and the aging brain. Nutr Rev. 2010 Dec;68 Suppl 2:S102-11. doi: 10.1111/j.1753-4887.2010.00345.x. Review.  PubMed PMID: 21091943. 

      17: Frautschy SA, Cole GM. Why pleiotropic interventions are needed for Alzheimer's disease. Mol Neurobiol. 2010 Jun;41(2-3):392-409. doi: 10.1007/s12035-010-8137-1. Epub 2010 May 2. Review. PubMed PMID: 20437209; PubMed Central PMCID: PMC2876259. 

      18: Frautschy SA. Thinking outside the box about COX-1 in Alzheimer's disease. Neurobiol Dis. 2010 Jun;38(3):492-4. doi: 10.1016/j.nbd.2010.02.009. Epub 2010 Mar 2. PubMed PMID: 20206264. 

      19: Cole GM, Frautschy SA. Mechanisms of action of non-steroidal anti-inflammatory drugs for the prevention of Alzheimer's disease. CNS Neurol Disord Drug Targets. 2010 Apr;9(2):140-8. Review. PubMed PMID: 20205646. 

      20: Cole GM, Frautschy SA. DHA may prevent age-related dementia. J Nutr. 2010 Apr;140(4):869-74. doi: 10.3945/jn.109.113910. Epub 2010 Feb 24. Review. PubMed PMID: 20181786; PubMed Central PMCID: PMC2838628. 

      21: Ramanathan L, Hu S, Frautschy SA, Siegel JM. Short-term total sleep deprivation in the rat increases antioxidant responses in multiple brain regions  without impairing spontaneous alternation behavior. Behav Brain Res. 2010 Mar 5;207(2):305-9. doi: 10.1016/j.bbr.2009.10.014. Epub 2009 Oct 20. PubMed PMID: 19850085; PubMed Central PMCID: PMC2815069. 

      22: Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM. Beta-amyloid oligomers induce  phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci. 2009 Jul 15;29(28):9078-89. doi: 10.1523/JNEUROSCI.1071-09.2009. PubMed PMID: 19605645. 

      23: Cole GM, Ma QL, Frautschy SA. Omega-3 fatty acids and dementia. Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):213-21. doi: 10.1016/j.plefa.2009.05.015. Epub 2009 Jun 12. Review. PubMed PMID: 19523795. 

      24: Ercoli LM, Siddarth P, Kepe V, Miller KJ, Huang SC, Cole GM, Lavretsky H, Bookheimer SY, Kim J, Phelps ME, Barrio JR, Small GW. Differential FDDNP PET patterns in nondemented middle-aged and older adults. Am J Geriatr Psychiatry. 2009 May;17(5):397-406. doi: 10.1097/JGP.0b013e318198750b. PubMed PMID: 19390297; PubMed Central PMCID: PMC2882200. 

      25: Ma QL, Galasko DR, Ringman JM, Vinters HV, Edland SD, Pomakian J, Ubeda OJ, Rosario ER, Teter B, Frautschy SA, Cole GM. Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid. Arch Neurol. 2009 Apr;66(4):448-57. doi: 10.1001/archneurol.2009.22. PubMed PMID: 19364929; PubMed Central PMCID: PMC2742778. 

      26: Small GW, Siddarth P, Burggren AC, Kepe V, Ercoli LM, Miller KJ, Lavretsky H, Thompson PM, Cole GM, Huang SC, Phelps ME, Bookheimer SY, Barrio JR. Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia. Arch Gen Psychiatry. 2009 Jan;66(1):81-7. doi: 10.1001/archgenpsychiatry.2008.516. PubMed PMID: 19124691; PubMed Central PMCID: PMC2693405. 

      27: Begum AN, Yang F, Teng E, Hu S, Jones MR, Rosario ER, Beech W, Hudspeth B, Ubeda OJ, Cole GM, Frautschy SA. Use of copper and insulin-resistance to accelerate cognitive deficits and synaptic protein loss in a rat Abeta-infusion Alzheimer's disease model. J Alzheimers Dis. 2008 Dec;15(4):625-40. PubMed PMID:  19096161. 

      28: Hu S, Begum AN, Jones MR, Oh MS, Beech WK, Beech BH, Yang F, Chen P, Ubeda OJ, Kim PC, Davies P, Ma Q, Cole GM, Frautschy SA. GSK3 inhibitors show benefits  in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in  control animals. Neurobiol Dis. 2009 Feb;33(2):193-206. doi: 10.1016/j.nbd.2008.10.007. Epub 2008 Nov 5. PubMed PMID: 19038340. 

      29: Hu S, Ying Z, Gomez-Pinilla F, Frautschy SA. Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus. Brain Res. 2009 Jan 16;1249:191-201. doi: 10.1016/j.brainres.2008.10.054. Epub 2008 Nov 5. PubMed PMID: 19014914; PubMed Central PMCID: PMC3307371. 

      30: Ringman JM, Younkin SG, Pratico D, Seltzer W, Cole GM, Geschwind DH, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario ER, Gylys KH, Varpetian A, Medina LD, Cummings JL. Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology. 2008 Jul 8;71(2):85-92. doi: 10.1212/01.wnl.0000303973.71803.81. Epub 2008 May 28. PubMed PMID: 18509095. 

      31: Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH. Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. Am J Pathol. 2008 Jun;172(6):1683-92. doi: 10.2353/ajpath.2008.070829. Epub 2008 May 8. PubMed PMID: 18467692; PubMed Central PMCID: PMC2408427. 

      32: Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA,  Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation  and Alzheimer's disease. J Pharmacol Exp Ther. 2008 Jul;326(1):196-208. doi: 10.1124/jpet.108.137455. Epub 2008 Apr 16. PubMed PMID: 18417733; PubMed Central  PMCID: PMC2527621. 

      33: Ma QL, Yang F, Calon F, Ubeda OJ, Hansen JE, Weisbart RH, Beech W, Frautschy  SA, Cole GM. p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis. J Biol Chem. 2008 May 16;283(20):14132-43. doi: 10.1074/jbc.M708034200. Epub 2008 Mar 17. PubMed PMID: 18347024; PubMed Central PMCID: PMC2376243. 

      34: Kotilinek LA, Westerman MA, Wang Q, Panizzon K, Lim GP, Simonyi A, Lesne S, Falinska A, Younkin LH, Younkin SG, Rowan M, Cleary J, Wallis RA, Sun GY, Cole G, Frautschy S, Anwyl R, Ashe KH. Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain. 2008  Mar;131(Pt 3):651-64. doi: 10.1093/brain/awn008. PubMed PMID: 18292081; PubMed Central PMCID: PMC2628581. 

      35: Small GW, Bookheimer SY, Thompson PM, Cole GM, Huang SC, Kepe V, Barrio JR. Current and future uses of neuroimaging for cognitively impaired patients. Lancet Neurol. 2008 Feb;7(2):161-72. doi: 10.1016/S1474-4422(08)70019-X. Review. PubMed  PMID: 18207114; PubMed Central PMCID: PMC2728702. 

      36: Ma QL, Teter B, Ubeda OJ, Morihara T, Dhoot D, Nyby MD, Tuck ML, Frautschy SA, Cole GM. Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention. J Neurosci. 2007 Dec 26;27(52):14299-307. PubMed PMID: 18160637; PubMed Central PMCID: PMC2628584. 

      37: Ma QL, Harris-White ME, Ubeda OJ, Simmons M, Beech W, Lim GP, Teter B, Frautschy SA, Cole GM. Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer's models. J Neurochem. 2007 Nov;103(4):1594-607.  Epub 2007 Aug 30. PubMed PMID: 17760871; PubMed Central PMCID: PMC2527620. 

      38: Cole GM, Teter B, Frautschy SA. Neuroprotective effects of curcumin. Adv Exp  Med Biol. 2007;595:197-212. Review. PubMed PMID: 17569212; PubMed Central PMCID:  PMC2527619. 

      39: Small GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, Lavretsky  H, Burggren AC, Cole GM, Vinters HV, Thompson PM, Huang SC, Satyamurthy N, Phelps ME, Barrio JR. PET of brain amyloid and tau in mild cognitive impairment. N Engl  J Med. 2006 Dec 21;355(25):2652-63. PubMed PMID: 17182990. 

      40: Cole GM, Frautschy SA. Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model. Nutr Health. 2006;18(3):249-59. Review. PubMed PMID: 17180870. 

      41: Cole GM, Frautschy SA. The role of insulin and neurotrophic factor signaling  in brain aging and Alzheimer's Disease. Exp Gerontol. 2007 Jan-Feb;42(1-2):10-21. Epub 2006 Oct 17. Review. PubMed PMID: 17049785. 

      42: Cole GM, Frautschy SA. Commentary on "Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery." Pleiotropic approaches to Alzheimer's and other diseases of aging. Alzheimers Dement. 2006 Oct;2(4):284-6. doi: 10.1016/j.jalz.2006.08.006. PubMed PMID: 19595901. 

      43: Cole GM, Frautschy SA. Cat and mouse. Neuron. 2006 Sep 21;51(6):671-2. PubMed PMID: 16982408. 

      44: Cole GM, Frautschy SA. Alzheimer's amyloid story finds its star. Trends Mol Med. 2006 Sep;12(9):395-6. Epub 2006 Aug 1. PubMed PMID: 16880006. 

      45: Malm T, Ort M, T√§htivaara L, Jukarainen N, Goldsteins G, Puoliv√§li J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen TK, Kanninen K, Leskinen S, Vartiainen N, Yrj√§nheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures  J, Koistinaho J. beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8852-7. Epub 2006 May 24. PubMed PMID: 16723396; PubMed Central PMCID: PMC1482667. 

      46: Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat Neurosci. 2006 Feb;9(2):234-42. Epub 2006 Jan 15. PubMed PMID: 16415866. 

      47: Kepe V, Barrio JR, Huang SC, Ercoli L, Siddarth P, Shoghi-Jadid K, Cole GM, Satyamurthy N, Cummings JL, Small GW, Phelps ME. Serotonin 1A receptors in the living brain of Alzheimer's disease patients. Proc Natl Acad Sci U S A. 2006 Jan  17;103(3):702-7. Epub 2006 Jan 9. PubMed PMID: 16407119; PubMed Central PMCID: PMC1334681. 

      48: Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe CG, Teter B, Frautschy SA, Cole GM. Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. J Neurosci Res. 2006 Feb 15;83(3):374-84. PubMed PMID: 16385556. 

      49: Gylys KH, Fein JA, Yang F, Miller CA, Cole GM. Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex. Neurobiol Aging.  2007 Jan;28(1):8-17. Epub 2005 Dec 5. PubMed PMID: 16332401. 

      50: Cole GM, Lim GP, Yang F, Teter B, Begum A, Ma Q, Harris-White ME, Frautschy SA. Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions. Neurobiol Aging. 2005 Dec;26 Suppl 1:133-6. Epub 2005 Nov 2. Review. PubMed PMID: 16266772. 

      51: Harris-White ME, Frautschy SA. Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition. Curr Drug Targets CNS Neurol Disord.  2005 Oct;4(5):469-80. Review. PubMed PMID: 16266282. 

      52: Calon F, Lim GP, Morihara T, Yang F, Ubeda O, Salem N Jr, Frautschy SA, Cole  GM. Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's  disease. Eur J Neurosci. 2005 Aug;22(3):617-26. PubMed PMID: 16101743. 

      53: Heath DD, Pruitt MA, Brenner DE, Begum AN, Frautschy SA, Rock CL. Tetrahydrocurcumin in plasma and urine: quantitation by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):206-12. PubMed PMID: 16061427. 

      54: Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL. A potential role of the curry spice curcumin in Alzheimer's disease. Curr Alzheimer Res. 2005 Apr;2(2):131-6. Review. PubMed PMID: 15974909; PubMed Central PMCID: PMC1702408. 

      55: Xie Z, Harris-White ME, Wals PA, Frautschy SA, Finch CE, Morgan TE. Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro. J Neurochem. 2005 May;93(4):1038-46. PubMed PMID: 15857407. 

      56: Lim GP, Calon F, Morihara T, Yang F, Teter B, Ubeda O, Salem N Jr, Frautschy  SA, Cole GM. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci. 2005 Mar 23;25(12):3032-40. PubMed PMID: 15788759. 

      57: Morihara T, Teter B, Yang F, Lim GP, Boudinot S, Boudinot FD, Frautschy SA, Cole GM. Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models. Neuropsychopharmacology. 2005 Jun;30(6):1111-20. PubMed PMID: 15688088. 

      58: Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA. NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models. Ann N Y Acad Sci. 2004 Dec;1035:68-84. Review. PubMed PMID: 15681801. 

      59: Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ, Frautschy SA, Cole GM. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. J Neurosci. 2004 Dec 8;24(49):11120-6. PubMed PMID: 15590928. 

      60: Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18;280(7):5892-901. Epub 2004 Dec 7. PubMed PMID: 15590663. 

      61: Weisbart RH, Hansen JE, Chan G, Wakelin R, Chang SS, Heinze E, Miller CW, Koeffler PH, Yang F, Cole GM, Min YS, Nishimura RN. Antibody-mediated transduction of p53 selectively kills cancer cells. Int J Oncol. 2004 Dec;25(6):1867-73. PubMed PMID: 15547728. 

      62: Gylys KH, Fein JA, Yang F, Wiley DJ, Miller CA, Cole GM. Synaptic changes in  Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. Am J Pathol. 2004 Nov;165(5):1809-17. PubMed PMID: 15509549; PubMed Central PMCID: PMC1618663. 

      63: Craft JM, Watterson DM, Frautschy SA, Van Eldik LJ. Aminopyridazines inhibit  beta-amyloid-induced glial activation and neuronal damage in vivo. Neurobiol Aging. 2004 Nov-Dec;25(10):1283-92. PubMed PMID: 15465624. 

      64: Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N Jr, Ashe KH, Frautschy SA, Cole GM. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron. 2004 Sep 2;43(5):633-45. PubMed PMID: 15339646; PubMed Central PMCID: PMC2442162. 

      65: Gylys KH, Fein JA, Yang F, Cole GM. Enrichment of presynaptic and postsynaptic markers by size-based gating analysis of synaptosome preparations from rat and human cortex. Cytometry A. 2004 Jul;60(1):90-6. PubMed PMID: 15229861. 

      66: Harris-White ME, Balverde Z, Lim GP, Kim P, Miller SA, Hammer H, Galasko D, Frautschy SA. Role of LRP in TGFbeta2-mediated neuronal uptake of Abeta and effects on memory. J Neurosci Res. 2004 Jul 15;77(2):217-28. PubMed PMID: 15211588. 

      67: D'Andrea MR, Cole GM, Ard MD. The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol Aging. 2004 May-Jun;25(5):675-83. Review. PubMed PMID: 15172747. 

      68: Gylys KH, Fein JA, Wiley DJ, Cole GM. Rapid annexin-V labeling in synaptosomes. Neurochem Int. 2004 Feb;44(3):125-31. PubMed PMID: 14568554. 

      69: Cole GM. Ironic fate: can a banned drug control metal heavies in neurodegenerative diseases? Neuron. 2003 Mar 27;37(6):889-90. PubMed PMID: 12670416. 

      70: Weisbart RH, Yang F, Chan G, Wakelin R, Ferreri K, Zack DJ, Harrison B, Leinwand LA, Cole GM. Cell type specific targeted intracellular delivery into muscle of a monoclonal antibody that binds myosin IIb. Mol Immunol. 2003 Mar;39(13):783-9. PubMed PMID: 12617993. 

      71: Agdeppa ED, Kepe V, Petri A, Satyamurthy N, Liu J, Huang SC, Small GW, Cole GM, Barrio JR. In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile . Neuroscience. 2003;117(3):723-30. PubMed PMID: 12617976. 

      72: Gylys KH, Fein JA, Tan AM, Cole GM. Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals. J Neurochem. 2003 Mar;84(6):1442-51. PubMed PMID: 12614344. 

      73: Tomioka M, Shirotani K, Iwata N, Lee HJ, Yang F, Cole GM, Seyama Y, Saido TC. In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons. Brain Res Mol Brain Res. 2002 Dec;108(1-2):18-32. PubMed PMID: 12480175. 

      74: Morihara T, Chu T, Ubeda O, Beech W, Cole GM. Selective inhibition of Abeta42 production by NSAID R-enantiomers. J Neurochem. 2002 Nov;83(4):1009-12. PubMed PMID: 12421374. 

      75: Gylys KH, Fein JA, Cole GM. Caspase inhibition protects nerve terminals from  in vitro degradation. Neurochem Res. 2002 Jun;27(6):465-72. PubMed PMID: 12199150. 

      76: Teter B, Xu PT, Gilbert JR, Roses AD, Galasko D, Cole GM. Defective neuronal  sprouting by human apolipoprotein E4 is a gain-of-negative function. J Neurosci Res. 2002 May 1;68(3):331-6. PubMed PMID: 12111863. 

      77: Bertrand E, Brouillet E, Caill√© I, Bouillot C, Cole GM, Prochiantz A, Allinquant B. A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo. Mol Cell Neurosci. 2001 Nov;18(5):503-11. PubMed  PMID: 11922141. 

      78: Rossiter JP, Anderson LL, Yang F, Cole GM. Caspase-3 activation and caspase-like proteolytic activity in human perinatal hypoxic-ischemic brain injury. Acta Neuropathol. 2002 Jan;103(1):66-73. PubMed PMID: 11841033. 

      79: Sun X, Cole GM, Chu T, Xia W, Galasko D, Yamaguchi H, Tanemura K, Frautschy SA, Takashima A. Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines. Neurobiol Aging. 2002 Mar-Apr;23(2):195-203. PubMed PMID: 11804703. 

      80: Frautschy SA, Hu W, Kim P, Miller SA, Chu T, Harris-White ME, Cole GM. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging. 2001 Nov-Dec;22(6):993-1005. PubMed PMID: 11755008. 

      81: Lim GP, Yang F, Chu T, Gahtan E, Ubeda O, Beech W, Overmier JB, Hsiao-Ashec K, Frautschy SA, Cole GM. Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging. 2001 Nov-Dec;22(6):983-91. PubMed PMID: 11755007. 

      82: Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A, Cole GM, Small GW, Huang SC, Barrio JR. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci. 2001  Dec 15;21(24):RC189. PubMed PMID: 11734604. 

      83: Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001 Nov 1;21(21):8370-7. PubMed PMID: 11606625. 

      84: Harris-White ME, Chu T, Miller SA, Simmons M, Teter B, Nash D, Cole GM, Frautschy SA. Estrogen (E2) and glucocorticoid (Gc) effects on microglia and A beta clearance in vitro and in vivo. Neurochem Int. 2001 Nov-Dec;39(5-6):435-48.  PubMed PMID: 11578779. 

      85: Chen TA, Yang F, Cole GM, Chan SO. Inhibition of caspase-3-like activity reduces glutamate induced cell death in adult rat retina. Brain Res. 2001 Jun 15;904(1):177-88. PubMed PMID: 11516428. 

      86: Adamec E, Yang F, Cole GM, Nixon RA. Multiple-label immunocytochemistry for the evaluation of nature of cell death in experimental models of neurodegeneration. Brain Res Brain Res Protoc. 2001 Jul;7(3):193-202. PubMed PMID: 11431120. 

      87: Cole GM, Frautschy SA. Church baptizes Joseph and Perry. Eccentric views absolved. Neurobiol Aging. 2001 Jan-Feb;22(1):147-50; discussion 161-3. PubMed PMID: 11164288. 

      88: de Boer RA, van Veldhuisen DJ, van der Wijk J, Brouwer RM, de Jonge N, Cole GM, Suurmeijer AJ. Additional use of immunostaining for active caspase 3 and cleaved actin and PARP fragments to detect apoptosis in patients with chronic heart failure. J Card Fail. 2000 Dec;6(4):330-7. PubMed PMID: 11145758. 

      89: Cole GM, Ard MD. Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein. Microsc Res Tech. 2000 Aug 15;50(4):316-24. Review. PubMed PMID: 10936886. 

      90: Rossiter JP, Anderson LL, Yang F, Cole GM. Caspase-cleaved actin (fractin) immunolabelling of Hirano bodies. Neuropathol Appl Neurobiol. 2000 Aug;26(4):342-6. PubMed PMID: 10931367. 

      91: Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA, Cole GM. Ibuprofen suppresses plaque pathology and inflammation in  a mouse model for Alzheimer's disease. J Neurosci. 2000 Aug 1;20(15):5709-14. PubMed PMID: 10908610. 

      92: Gylys KH, Fein JA, Cole GM. Quantitative characterization of crude synaptosomal fraction (P-2) components by flow cytometry. J Neurosci Res. 2000 Jul 15;61(2):186-92. PubMed PMID: 10878591. 

      93: Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T. Inflammation and Alzheimer's disease. Neurobiol Aging. 2000 May-Jun;21(3):383-421. Review. PubMed PMID: 10858586. 

      94: Horsburgh K, Cole GM, Yang F, Savage MJ, Greenberg BD, Gentleman SM, Graham DI, Nicoll JA. beta-amyloid (Abeta)42(43), abeta42, abeta40 and apoE immunostaining of plaques in fatal head injury. Neuropathol Appl Neurobiol. 2000  Apr;26(2):124-32. PubMed PMID: 10840275. 

      95: Lankiewicz S, Marc Luetjens C, Truc Bui N, Krohn AJ, Poppe M, Cole GM, Saido  TC, Prehn JH. Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death. J Biol Chem. 2000 Jun 2;275(22):17064-71. PubMed  PMID: 10828077. 

      96: McCarron MO, Nicoll JA, Stewart J, Cole GM, Yang F, Ironside JW, Mann DM, Love S, Graham DI. Amyloid beta-protein length and cerebral amyloid angiopathy-related haemorrhage. Neuroreport. 2000 Apr 7;11(5):937-40. PubMed PMID: 10790859. 

      97: Yang F, Ubeda K, Chen P, Ashe KH, Cole GM. Plaque-associated alpha-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein. Brain Res. 2000 Jan 24;853(2):381-3. PubMed PMID: 10640638. 

      98: Teter B, Xu PT, Gilbert JR, Roses AD, Galasko D, Cole GM. Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture. J Neurochem. 1999 Dec;73(6):2613-6. PubMed PMID: 10582625. 

      99: Mega MS, Chu T, Mazziotta JC, Trivedi KH, Thompson PM, Shah A, Cole G, Frautschy SA, Toga AW. Mapping biochemistry to metabolism: FDG-PET and amyloid burden in Alzheimer's disease. Neuroreport. 1999 Sep 29;10(14):2911-7. PubMed PMID: 10549796. 

      100: Cole GM, Beech W, Frautschy SA, Sigel J, Glasgow C, Ard MD. Lipoprotein effects on Abeta accumulation and degradation by microglia in vitro. J Neurosci Res. 1999 Aug 15;57(4):504-20. PubMed PMID: 10440900. 

      101: Teter B, Harris-White ME, Frautschy SA, Cole GM. Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures. Neuroscience. 1999;91(3):1009-16. PubMed PMID: 10391478. 

      102: Suurmeijer AJ, van der Wijk J, van Veldhuisen DJ, Yang F, Cole GM. Fractin immunostaining for the detection of apoptotic cells and apoptotic bodies in formalin-fixed and paraffin-embedded tissue. Lab Invest. 1999 May;79(5):619-20. PubMed PMID: 10334574. 

      103: Panizzon KL, Shin D, Frautschy S, Wallis RA. Neuroprotection with Bcl-2(20-34) peptide against trauma. Neuroreport. 1998 Dec 21;9(18):4131-6. PubMed PMID: 9926861. 

      104: Harris-White ME, Chu T, Balverde Z, Sigel JJ, Flanders KC, Frautschy SA. Effects of transforming growth factor-beta (isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures. J Neurosci. 1998 Dec 15;18(24):10366-74. PubMed PMID: 9852574. 

      105: Pulera MR, Adams LM, Liu H, Santos DG, Nishimura RN, Yang F, Cole GM, Wasterlain CG. Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia. Stroke. 1998 Dec;29(12):2622-30. PubMed PMID: 9836776. 

      106: Chu T, Tran T, Yang F, Beech W, Cole GM, Frautschy SA. Effect of chloroquine and leupeptin on intracellular accumulation of amyloid-beta (A beta) 1-42 peptide in a murine N9 microglial cell line. FEBS Lett. 1998 Oct 9;436(3):439-44. PubMed  PMID: 9801165. 

      107: Frautschy SA, Horn DL, Sigel JJ, Harris-White ME, Mendoza JJ, Yang F, Saido  TC, Cole GM. Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain. J Neurosci. 1998 Oct 15;18(20):8311-21. PubMed PMID: 9763475. 

      108: Cummings JL, Vinters HV, Cole GM, Khachaturian ZS. Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology. 1998 Jul;51(1 Suppl 1):S2-17; discussion S65-7. Review. PubMed PMID: 9674758. 

      109: Harris-White ME, Zanotti SA, Frautschy SA, Charles AC. Spiral intercellular  calcium waves in hippocampal slice cultures. J Neurophysiol. 1998 Feb;79(2):1045-52. PubMed PMID: 9463460. 

      110: Yang F, Sun X, Beech W, Teter B, Wu S, Sigel J, Vinters HV, Frautschy SA, Cole GM. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am J Pathol. 1998 Feb;152(2):379-89. PubMed PMID: 9466564; PubMed Central PMCID:  PMC1857963. 

      111: Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM. Microglial response to amyloid plaques in APPsw transgenic mice. Am J Pathol. 1998 Jan;152(1):307-17. PubMed PMID: 9422548; PubMed Central PMCID: PMC1858113. 

      112: Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. Neurobiol Aging. 1996 Jul-Aug;17(4):653-9. PubMed PMID: 8832640. 

      113: Frautschy SA, Yang F, Calder√≥n L, Cole GM. Rodent models of Alzheimer's disease: rat A beta infusion approaches to amyloid deposits. Neurobiol Aging. 1996 Mar-Apr;17(2):311-21. PubMed PMID: 8744413. 

      114: Tekirian TL, Cole GM, Russell MJ, Yang F, Wekstein DR, Patel E, Snowdon DA,  Markesbery WR, Geddes JW. Carboxy terminal of beta-amyloid deposits in aged human, canine, and polar bear brains. Neurobiol Aging. 1996 Mar-Apr;17(2):249-57. PubMed PMID: 8744406. 

      115: Ard MD, Cole GM, Wei J, Mehrle AP, Fratkin JD. Scavenging of Alzheimer's amyloid beta-protein by microglia in culture. J Neurosci Res. 1996 Jan 15;43(2):190-202. PubMed PMID: 8820967. 

      116: Hanneken A, Frautschy S, Galasko D, Baird A. A fibroblast growth factor binding protein in human cerebral spinal fluid. Neuroreport. 1995 Apr 19;6(6):886-8. PubMed PMID: 7612876. 

      117: Frautschy SA, Sarkar DK. Estrogen augments hypothalamicBETA-endorphin secretion and activates an inhibitoryBETA-endorphin short-loop feedback system. Endocrine. 1995 Apr;3(4):273-5. doi: 10.1007/BF03021405. PubMed PMID: 21153174. 

      118: Mak K, Yang F, Vinters HV, Frautschy SA, Cole GM. Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum. Brain Res. 1994 Dec 19;667(1):138-42. PubMed PMID: 7895077. 

      119: Yang F, Mak K, Vinters HV, Frautschy SA, Cole GM. Monoclonal antibody to the C-terminus of beta-amyloid. Neuroreport. 1994 Oct 27;5(16):2117-20. PubMed PMID:  7865758. 

      120: Mufson EJ, Benzing WC, Cole GM, Wang H, Emerich DF, Sladek JR Jr, Morrison JH, Kordower JH. Apolipoprotein E-immunoreactivity in aged rhesus monkey cortex:  colocalization with amyloid plaques. Neurobiol Aging. 1994 Sep-Oct;15(5):621-7. PubMed PMID: 7824054. 

      121: Winkler J, Connor DJ, Frautschy SA, Behl C, Waite JJ, Cole GM, Thal LJ. Lack of long-term effects after beta-amyloid protein injections in rat brain. Neurobiol Aging. 1994 Sep-Oct;15(5):601-7. PubMed PMID: 7824051. 

      122: Logan A, Berry M, Gonzalez AM, Frautschy SA, Sporn MB, Baird A. Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat. Eur J Neurosci. 1994 Mar 1;6(3):355-63. PubMed PMID: 8019673. 

      123: Cole GM, Bell L, Truong QB, Saitoh T. An endosomal-lysosomal pathway for degradation of amyloid precursor protein. Ann N Y Acad Sci. 1992 Dec 31;674:103-17. PubMed PMID: 1288357. 

      124: Logan A, Frautschy SA, Gonzalez AM, Baird A. A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury. J Neurosci. 1992 Oct;12(10):3828-37. PubMed PMID: 1403086. 

      125: Waite J, Cole GM, Frautschy SA, Connor DJ, Thal LJ. Solvent effects on beta  protein toxicity in vivo. Neurobiol Aging. 1992 Sep-Oct;13(5):595-9. PubMed PMID: 1461348. 

      126: Logan A, Frautschy SA, Gonzalez AM, Sporn MB, Baird A. Enhanced expression of transforming growth factor beta 1 in the rat brain after a localized cerebral  injury. Brain Res. 1992 Aug 7;587(2):216-25. PubMed PMID: 1525658. 

      127: Behl C, Davis J, Cole GM, Schubert D. Vitamin E protects nerve cells from amyloid beta protein toxicity. Biochem Biophys Res Commun. 1992 Jul 31;186(2):944-50. PubMed PMID: 1497677. 

      128: Sarkar DK, Frautschy SA, Mitsugi N. Pituitary portal plasma levels of oxytocin during the estrous cycle, lactation, and hyperprolactinemia. Ann N Y Acad Sci. 1992 Jun 12;652:397-410. PubMed PMID: 1626839. 

      129: Frautschy SA, Cole GM, Baird A. Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid. Am J Pathol. 1992 Jun;140(6):1389-99. PubMed PMID: 1376558; PubMed Central PMCID: PMC1886549. 

      131: Frautschy SA, Baird A, Cole GM. Effects of injected Alzheimer beta-amyloid cores in rat brain. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8362-6. PubMed PMID: 1924295; PubMed Central PMCID: PMC52508. 

      132: Masliah E, Cole GM, Hansen LA, Mallory M, Albright T, Terry RD, Saitoh T. Protein kinase C alteration is an early biochemical marker in Alzheimer's disease. J Neurosci. 1991 Sep;11(9):2759-67. PubMed PMID: 1880547. 

      133: Frautschy SA, Walicke PA, Baird A. Localization of basic fibroblast growth factor and its mRNA after CNS injury. Brain Res. 1991 Jul 12;553(2):291-9. PubMed PMID: 1933286. 

      134: Frautschy SA, Gonzalez AM, Martinez Murillo R, Carceller F, Cuevas P, Baird  A. Expression of basic fibroblast growth factor and its receptor in the rat subfornical organ. Neuroendocrinology. 1991 Jul;54(1):55-61. PubMed PMID: 1656299. 

      135: Saitoh T, Masliah E, Jin LW, Cole GM, Wieloch T, Shapiro IP. Protein kinases and phosphorylation in neurologic disorders and cell death. Lab Invest. 1991 May;64(5):596-616. Review. PubMed PMID: 2030574. 

      136: Cole GM, Masliah E, Shelton ER, Chan HW, Terry RD, Saitoh T. Accumulation of amyloid precursor fragment in Alzheimer plaques. Neurobiol Aging. 1991 Mar-Apr;12(2):85-91. PubMed PMID: 1711161. 

      137: Cole GM, Reed SI. Pheromone-induced phosphorylation of a G protein beta subunit in S. cerevisiae is associated with an adaptive response to mating pheromone. Cell. 1991 Feb 22;64(4):703-16. PubMed PMID: 1900039. 

      138: Logan A, Frautschy SA, Baird A. Basic fibroblast growth factor and central nervous system injury. Ann N Y Acad Sci. 1991;638:474-6. PubMed PMID: 1785823. 

      139: Cole GM, Galasko D, Shapiro IP, Saitoh T. Stimulated platelets release amyloid beta-protein precursor. Biochem Biophys Res Commun. 1990 Jul 16;170(1):288-95. PubMed PMID: 2115331. 

      140: Minami S, Frautschy SA, Plotsky PM, Sutton SW, Sarkar DK. Facilitatory role  of neuropeptide Y on the onset of puberty: effect of immunoneutralization of neuropeptide Y on the release of luteinizing hormone and luteinizing-hormone-releasing hormone. Neuroendocrinology. 1990 Jul;52(1):112-5.  PubMed PMID: 2118604. 

      141: Cole GM, Stone DE, Reed SI. Stoichiometry of G protein subunits affects the  Saccharomyces cerevisiae mating pheromone signal transduction pathway. Mol Cell Biol. 1990 Feb;10(2):510-7. PubMed PMID: 2105453; PubMed Central PMCID: PMC360826. 

      142: Kushner PD, Stephenson DT, Wright S, Cole GM, Greco CM. Monoclonal antibody  Tor 23 binds a subset of neural cells in the human cortex and displays an altered binding distribution in Alzheimer's disease. J Neuropathol Exp Neurol. 1989 Nov;48(6):692-708. PubMed PMID: 2677253. 

      143: Cole GM, Huynh TV, Saitoh T. Evidence for lysosomal processing of amyloid beta-protein precursor in cultured cells. Neurochem Res. 1989 Oct;14(10):933-9. PubMed PMID: 2514387. 

      144: Frautschy SA, Gaon D, Liptrap RM. Effect of dexamethasone on gonadotrophin secretion in the gonadectomized sow and boar. Can J Vet Res. 1989 Oct;53(4):490-2. PubMed PMID: 2512005; PubMed Central PMCID: PMC1255582. 

      145: Sarkar DK, Friedman SJ, Yen SS, Frautschy SA. Chronic inhibition of hypothalamic-pituitary-ovarian axis and body weight gain by brain-directed delivery of estradiol-17 beta in female rats. Neuroendocrinology. 1989 Aug;50(2):204-10. PubMed PMID: 2674763. 

      146: Frautschy SA, Liptrap RM. Anovulation and plasma hormone concentrations after administration of dexamethasone during the middle of the luteal phase in sows undergoing estrous cycles. Am J Vet Res. 1988 Aug;49(8):1270-5. PubMed PMID: 3140694. 

      147: Love S, Saitoh T, Quijada S, Cole GM, Terry RD. Alz-50, ubiquitin and tau immunoreactivity of neurofibrillary tangles, Pick bodies and Lewy bodies. J Neuropathol Exp Neurol. 1988 Jul;47(4):393-405. PubMed PMID: 2838588. 

      148: Sternberg H, Baudier J, Akizuki K, Cole GM, Martin WH, Creutz CE, Timiras PS, David Cole R. Similarities and differences between tau protein and chromobindin A. Neurochem Int. 1988;13(2):149-52. PubMed PMID: 20501283. 

      149: Kushner PD, Cole GM, Sternberg H, Woloshin PI. A human teratocarcinoma which expresses a rare neuronal cell surface antigen. Brain Res. 1987 Sep;388(3):271-5. PubMed PMID: 3315107. 

      150: Cole GM, Timiras PS. Ubiquitin-protein conjugates in Alzheimer's lesions. Neurosci Lett. 1987 Aug 18;79(1-2):207-12. PubMed PMID: 2823191.  

      151: Ino M, Cole GM, Timiras PS. Tyrosine hydroxylase and monoamine oxidase-A activity increases in differentiating human neuroblastoma after elimination of dividing cells. Brain Res. 1986 Nov;395(1):120-3. PubMed PMID: 2877718. 


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