Xiaoyan Sun, MD, PhD

Former Member UCLA Alzheimer Translation Center


xiaoyanXiaoyan Sun worked as one of the first post doctoral fellow in Dr. Frautschy and Cole's Lab from 1996-98. She was the first to show that caspase activation resulted in beta-amyloid release, suggesting that neuron damage would created a positive feedback cycle leading to a more beta-amyloid production..




1996 Ph.D. Gunma University School of Medicine, Japan Neuroscience 1984 M.D. Xi’an Medical College (Present name: School of Medicine, Xi’an Jiaotong University), China

2012-Present Fellow in Neurology, Boston VA Medical Center, Boston, MA

2009-2012 Resident in Neurology, Medical University of South Carolina, SC

2008-2009 Intern in Neurology, University of South Carolina, SC

2004-2008 Clinical Research Fellow, Dept Psychiatry, Tufts Medical center and School of Nutrition Science and Policy, Boston, MA

2002-2004 Postdoctoral Fellow, Dept of Neurology and Center for Neurologic Disease, Brigham and Woman’s Hospital, Harvard Medical School, Boston, MA

1996-1998 Postdoctoral Fellow, Dept Medicine, UCLA, CA

1983-1984 Intern, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, China

1998-2002 Staff Scientist, Brain Science Institute of RIKEN, Japan HOSPITAL


1989-1990 Attending, Dept Neurology, Qinghai Provincial People’s Hospital, China


1987-1987 Clinical fellowship, The Iodine Deficient Disorder (IDD) Project between China and Australia

1990-1991 Clinical fellowship of Neurology, Sasakawa Foundation, Japan

1992-1996 Japanese Government Scholarship for Ph.D course, Japan

1996-1997 Staff Incentive Award For Exceptional Performance And Valuable Contribution, Dept Medicine, UCLA 2010 Best Case Presentation Award, Dept Neuroscience, Medical University of South Carolina

License and Certification

2012 Board Certified Neurology

2012 South Carolina Medical License # 30195 2012 Massachusetts Medical License # 251388 1987 Psychometrics certificate, Ma


2012 Neurological examination for medical student in Medical University of South Carolina


2010-present Member of American Academy of Neurology


2008 Biological Psychiatry

2008 Journal of Affective Disorder

2008 American Journal of Psychiary

2012 American Journal of Alzheimer’s disease and other dementia 2013 Neuroscience Letter


1998-2000 Chinese Natural Science Foundation, Chinese Yen ¥120,000 2002-2003 Sabbatical Program In Drug Discovery, HCNR of Harvard Medical School


1     Okamoto K., Hirai S., Yamazaki T., Sun X., and Nakazato Y.  New ubiquitin-positive intraneuronal inclusions in the extra-motor cortices in patients with ALS Neurosci Lett  1991, 129:233-236
2     Tanaka M., Kondo S., Hirai S., Sun X., Yamagishi T., Okamoto K.. Cerebral blood flow and oxygen metabolism in progressive dementia associated with amyotrophic lateral sclerosis.  J  Neurol  Sci.  1993; 120:22-28
3     Kondo S., Tanaka  M.,  Sun X., Saka Y., Hirai S. Study of patients with spinocerebellar degeneration using positron emission tomography  Clin. Neurol., 1993; 33:1039-1049
4     Sun X, Tanaka T., Kondo S., Hirai S.,  Ishihara T.. Reduced cerebellar blood flow and oxygen metabolism  in spinocerebellar degeneration: a combined PET and MRI study  J Neurol. 1994; 241:295-300
5     Yamaguchi H., Yamazaki T., Kawarabayashi T., Sun X.,  Sakai Y,  Hirai S..  Localization of Alzheimer  amyloid beta protein precursor and its relation to senile plaque amyloid  Geronto.l  1994; 40(Suppl. 2): 36-45
6     Yamaguchi H., Ishigoro K., Sugihara S., Nakazato Y., Kawarabayashi T., Sun X. and Hirai S.. Presence of   apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition.  Acta. Neurpathologica.  1994;8:413-419
7     Sun X., Tashiro T., Hirai S. and  Yamaguchi H..  Identification of 5.8 kDa C-terminal fragments of Alzheimer amyloid generated in the lysosomal system. Amyloid:  Int.J.Exp.Clin.Invest. 1994;1:100-106
8     Kondo S., Tanaka  M., Sun X., Okamoto K., and  Hirai S..  Cerebral blood flow and oxygen metabolism
       in  patients with pure akinesia and progressive supranuclear palsy   Clin. Neurol. 1994; 34:531-537
9     Tanaka M., Uesugi M.,  Igeda Y, Kondo S.,  Sun X. and Hirai S..  Luxury perfusion phenomenon in acute herpes simplex virus encephalitis.  Annals of Nuclear Medicine 1995; 9:43-45
10   Sun X.,  Tashiro T., Hirai S., Yamamoto H.,  Miyamoto E., and  Komiya Y..  Preparation of tau from the peripheral nerve: Presence of insoluble low molecular weight tau with high phosphorylation   Biochem. Biophy. Res. Comm.  1995; 210:338-344
11   Tashiro T., Sun X., Tusda M., Komiya Y.  Differential axonal transport of soluble and insoluble tau in the rat sciatic nerve  J. Neurochem  1996; 67(4):1566-74
12   Yang F., Sun X.,  Beech W., Teter B.,  Wu S., Sigel J., Frautschy S. and Cole GM.  Detection of actin    cleavage at an apoptosis related site in vitro and in Alzheimer’s disease Am J Pathol 1998; 158:379-389
13   Sun X., Tanaka M., Kondo S., Okamoto K,  Hirai S. Clinical significance of reduced cerebral metabolism in multiple sclerosis: A combined PET and MRI study  Annals of Nuclear Medicine  1998 12(2): 89-94
14   Tanaka M., Hirai S., Kondo S, Sun X., Nakagawa T., Tanaka S., Hayashi K., Okamoto. Cerebral hypoperfusion and hypometabolism with altered striatal signal intensity in chorea-acanthocytosis: a combined PET and MRI study. Mov Disord. 1998 13(1):100-7
15   Murayama O., Murayama M.,  Honda T., Sun X, Nihonmatus N. and  Takashima A. Twenty-nine missense mutations linked with familial Alzheimer’s disease alter the processing of presenilin 1  Prog Neuro-Psychopharmacol & Biol Psychiat  1999  23: 905-913
16   Murayama O., Tomita T.,  Nihomatsu N., Murayama M., Sun X., Honda T., Iwatsubo T., Takashima A. Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheime’s disease. Neurosci Lett 199 265(1):61-3
17   Murayama M.,  Tanaka S., Palacino J.,  Murayama O,  Honda T.,   Sun X., Yasutake K., Nihonmatue-Kikuchi N., Wolozin B, and Takashima A.. Direct association of presenilin-1 with beta-catenin  FEBS Lett.  1998; 433:73-77
18   Tanemura K., Akagi T.,  Murayama M. ,  Kikuchi N.,  Murayama O.,   Hashikawa T., Yoshiike Y.,  Park J-M.,  Matsuda K.,  Nakao K.,  Sun X., Sato S.,  Yamaguchi H, and  Takashima A.   Neurobiol. of  Diseasees  2001; 8:1036-1045
19   Murayama M., Sun X., Takashima  A..  Synthesis of the His6-tagged recombinant protein APPC99 and His-Ps1 Using the RTS 500  Biochemica  2001, 4:24-26
20   Yoshiike Y., Tanemura K.,  Murayama O.,  Akagi T.,  Murayama M., Sato S.,  Sun X., Tanaka N., and Takashima A.  New insights on how metals disrupt amyloid beta-aggregation and their effects on amyloid-beta cytotoxicity  J Bio Chem  2001; 276(34):32293-9
21   Sun X., Cole GM,, Chu T., Xia W., Galasko D., Yamaguchi H.,  Frautschy SA., and  Takashima A..  Intracellular A-beta is increased by okadic acid exposure in the transfected neuronal and non-neuronal cell lines   Neurobiol. of Aging  2002; 23:195-203
22   Sun X.,  Sato S., ,  Murayama O.,  Murayama M., Park J.-M., Yamaguchi H., and  Takashima A. Lithium inhibits amyloid secretion in the cells transfected with amyloid  precursor protein C100  Neurosci Lett  2002; 321:61-64
23   Xia X., Wang P.,  Sun X., .Soriano S., Shum W.-K., Yamaguchi H., Trumbauer ME.,  Takashima A., Koo EH., and  Zheng H. The Aspartate 257 of presenilin 1 is indispensable for mouse development and Abeta production through beta-catenin independent Mechanisms Proc. Natl.Acad.Sci.USA  2002; 99:8760-8765
24   Leissring M.A., Farris W., Chang A.Y., Walsh D.M., Wu X., Sun X., Frosch M.P., Selkoe D.J.  Enhanced  proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and  premature death. Neuron. 2003 Dec 18;40(6):1087-93
25   Beglopoulos V*, Sun X.*, Saura R., Kim R., and Shen J. Reduced amyloid production and increased inflammatory responses in presenilin conditional knockout mic. J Biol Chem. 2004 Nov 5; 279 (45): 46907-14 (*equal contribution)
26   Zhang L., Lee J., Song L., Sun X., Shen J., Terracina G., Parker E.M..  Characterization of the Reconstituted gamma-Secretase Complex from Sf9 Cells Co-Expressing Presenilin 1, Nacastrin, aph-1a, and pen-2. Biochemistry. 2005 Mar 22;44(11):4450-7.
27   Sun X. *, Beglopoulos V*,., Mattson M, Shen J.. Hippocampal Spatial Memory Impairments Caused by the Familial Alzheimer’s Disease-linked Presenilin 1 M146V Mutation  Neurodegenerative Dis 2005; 2:6-15
28   Cruz  J.C.,  Kim D., Moy L.Y.,  Dobbin  M.M.,  Sun X., Bronson RT, and Tsai L.-H.. p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid β in vivo. J. of  Neurosci, October 11, 2006, 26(41):10536-10541
29   Qiu W.Q., Price L.L., Hibber P., Beull J., Collins L., Leins D., Mwamburi D.M., Rosenberg I.,  Smaldone  B.A., Scott T.M., Siegel R.D., Summergrad P., Sun X., Wagner  C., Wan  L., Yee J., Tucker K. and Folstein M..  Executive Dysfunction in Homebound Elderly with Diabetes  J Ameri Geria Soci 2006; 54: 456-501.
30   Qiu W.Q., *, Sun X., *, Selkoe D.J.,  Mwamburi D.M., Huang T. , Bhadela R.,  Bergethon P.,  Scott T.M.,  Summergrad P.,   Wang L.,  Rosenberg I.,  and Folstein M.  .  Depression is Associated with Low Plasma Ab42 Independently of Cardiovascular Disease in the Homebound Elderly. Int J. Ger Psych,  Nov. 6, 2006 (*equal contribution)
31   Sun X.,  Selkoe D.J., Mwamburi D.M., Bungay K., Prasad  J., Yee  J.,  Lin Y. , Liu T.C.,  Summergrad P.,  Folstein M. , and  Qiu  W.Q.  .  Depression, antidepressants and plasma Ab peptides in those elderly who do not have cardiovascular disease. Biological Psychiatry, 2007  Jun. 1;
32   Farris W., Schütz S.G., Cirrito J. R., Shankar G. M., Sun X., George A., Leissring M.,  Walsh D. M., Qiu W.Q., Holtzman D. M., Selkoe D. J.. Loss of neprilysin function promotes amyloid plaque formation and precipitates cerebral amyloid angiopathy. American Journal ofominic Pathology, 2007, 171(1):241-251.
33   Sun X., Steffens D.C., AU  R., Folstein M., Summergrad P., Yee J., Rosenberg I., Mwamburi D.M., Qiu W.Q.. Amyloid-associated depression: a prodromal depression of Alzheimer disease? Arch Gen Psych 2008, 65: 542-50
34   Okereke O.I., Xia W., Irizarry M.C., Sun X., Qiu W.Q., Fagan A.M., Mehta P.D., Hyman B.T., Selkoe D.J., Grodstein F.. Performance  of characteristics of  plasma amyloid-beta 40 and 42 assays.  J Alzheimers Dis.   2009;16(2):277-85.
35   Shankar G.M., Leissring M.A., Adame A., Sun X., Spooner E., Masliah E., Selkoe D, J,, Lemere C,A,,  Walsh D,M,. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis.  2009 Nov;36(2):293-302 
36   Sun X., Chiu C.C.,  Liebson E.,  Crivello N.A.,  Wang L.,  Folstein M.,  Rosenberg I.,  Mwamburi D.M.  ,  Peter I., and Qiu W.Q.    Depression and plasma Amyloid β peptides in the elderly with and without apolipoprotein E4 allele. Alzheimer Dis Assoc Disord.  2009 Jul-Sep;23(3):238-44.
37   Qiu W.Q., Sun X.,  Mwamburi, D.M., Haker J.,  Lisle D.,  Rizal A., Lin Y.,  Qiao L., Summergrad P., Wang L.,  Folstein M., and  Rosenberg I.. Plasma Amyloid-b and Homocysteine in Depression in the Homebound Elderly. North American Journal of  Medicine and Science,   2010 Vol 61-67
38   Sun X, Bhadelia R, Liebson E, Bergethon P, Folstein M, Zhu JJ, Mwamburi DM, Patz S, Qiu WQ. The relationship between plasma amyloid-β peptides and the medial temporal lobe in the homebound elderly. Int J Geriatr Psychiatry. 2010 Dec 9. [Epub ahead of print]
39   Sun X., Nicholas J., Walker A., Wagner M., and Bachman D. APOE genotype in the diagnosis of Alzheimer’s disease in the patients with cognitive impairment. American  Journal of Alzheimer’s disease and other dementia. 2012 Aug;27(5):315-20.


| Contact Us | | Home | Help Us | Site ||