Sally A. Frautschy, PhD

Alzheimer Research Lab

Professor UCLA Dept Neurology

Sally's research focuses on neuroinflammator mechanisms in Alzheimer's. Her priority is to develop practical and effective approaches, particularly nutritional, for stopping this tragic disease. She is currently conducting a clinical trial NCT01811381 combining yoga and curcumin with veterans at risk for Mild cognitive impairment with her coPI Edmond Teng, PhD, MD. This is based on extensive data from her and others work, supporting the fact that curcumin targets multiple aspects of the disease, not just oxidative damage, but corrects chronic ineffective inflammation as well as stimulates effective resolution of inflammation. Further it enhances a safe mechanism of removal of toxic aggregates, termed 'autophagy'.


Dr. Frautschy's focus in her graduate & initial post-graduate work was to understand the adverse effects of chronic stress on physiology, intrigued by the work of Hans Selye who in 1956 coined a word "stress" from physics to use to describe the physiological/chemical response to a psychological reaction. She worked under experts in the field of 'stress' , completing her MS under the late Gary Moberg at UC Davis in 1980 and PhD in 1986 under Professor Robert Liptrap, DVM, PHD at Univ. of Guelph, Ontario Canada (also a photographer.) After completing her Phd, she trained with Dipak Sarkar (UCSD, now at Rutgers) to study the mechanisms of inferitility caused by high levels of glucocorticoids, which results from chronic stress, a common problem which increases risk for several disease including PTSD and Alzheimer's. During her 2nd post doc with Dr. Andrew Baird & directorship of Roger Guillemin (a nobel laureate who did his post doc under Hans Selye), Sally worked on brain injury induction of neurotrophic factors where she began her collaboration with Dr. Cole . Many neurotrophic factors become elevated in the Alzheimer brain as a 'response' to injury. In 1988, Dr. Frautschy, in collaboration with Dr. Cole, decided to evaluate the brain's response to human amyloid, and was the first to describe the inflammatory response. She spends her spare time, doing yoga, running and taking care of her dogs

  • Frautschy, S.A., A. Baird, and G.M. Cole.  Effects of injected Alzheimer-amyloid cores in rat brain.  Proc. Natl. Acad. Sci. USA 88:8362-8366, 1991.

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