Sally A. Frautschy, PhD

Alzheimer

Research Lab

Professor

UCLA Dept Medicine & Neurology

• Selected peer-reviewed publications (from most recent).

  Cole GM, Frautschy SA. Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model.
  Nutr Health. 2006;18(3):249-59. Review.

• Cole GM, Frautschy SA. The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's Disease.Exp Gerontol. 2007 Jan-Feb;42(1-2):10-21. Epub 2006 Oct 17.

• Cole GM, Frautschy SA. Cat and mouse. Neuron. 2006 Sep 21;51(6):671-2.

• Cole GM, Frautschy SA. Alzheimer's amyloid story finds its star. Trends Mol Med. 2006 Sep;12(9):395-6. Epub 2006 Aug 1.

• Malm T, Ort M, Tahtivaara L, Jukarainen N, Goldsteins G, Puolivali J, Nurmi A, Pussinen R, Ahtoniemi T, Miettinen TK, Kanninen K, Leskinen S, Vartiainen N, Yrjanheikki J, Laatikainen R, Harris-White ME, Koistinaho M, Frautschy SA, Bures J, Koistinaho J. Free in PMC beta-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or beta-amyloid deposits. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8852-7. Epub 2006 May 24.
  

• Zhao L, Ma QL, Calon F, Harris-White ME, Yang F, Lim GP, Morihara T, Ubeda OJ, Ambegaokar S, Hansen JE, Weisbart RH, Teter B, Frautschy SA, Cole GM. Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.Nat Neurosci. 2006 Feb;9(2):234-42. Epub 2006 Jan 15.
  

• Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe CG, Teter B, Frautschy SA, Cole GM. Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. J Neurosci Res. 2006 Feb 15;83(3):374-84.
  

• Cole GM, Lim GP, Yang F, Teter B, Begum A, Ma Q, Harris-White ME, Frautschy SA. Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions. Neurobiol Aging. 2005 Dec;26 Suppl 1:133-6. Epub 2005 Nov 2. Review.

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  Harris-White ME, Frautschy SA. Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition. Curr Drug Targets CNS Neurol Disord. 2005 Oct;4(5):469-80. Review.

• Calon F, Lim GP, Morihara T, Yang F, Ubeda O, Salem N Jr, Frautschy SA, Cole GM. Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease.
  Eur J Neurosci. 2005 Aug;22(3):617-26.

• Heath DD, Pruitt MA, Brenner DE, Begum AN, Frautschy SA, Rock CL. Tetrahydrocurcumin in plasma and urine: quantitation by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):206-12.

• Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL. A potential role of the curry spice curcumin in Alzheimer's disease. Curr Alzheimer Res. 2005 Apr;2(2):131-6. Review.

• Xie Z, Harris-White ME, Wals PA, Frautschy SA, Finch CE, Morgan TE. Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro. J Neurochem. 2005 May;93(4):1038-46.
  

• G. P. Lim, F. Calon, T Morihara, F Yang, O. Ubeda, N. Salem, S A. Frautschy, and Greg M. Cole.  A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. 2005.  J. Neurosci.  25:3032-40 .

• L Zhao, B. Teter, T. Morihara, S.S. Ambegaokar, O.J. Ubeda, S.A. Frautschy, G.M. Cole. 2004.  Insulin-Degrading Enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.  J. Neuroscience. 24(49):11120 –11126
• Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.Curcumin Inhibits Formation of Amyloid {beta} Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo. J Biol Chem. 2005 Feb 18;280(7):5892-901
• F Calon, GP Lim, F Yang, O Ubeda, P Rostaing,A Triller, N Salem Jr., SA Frautschy &  G M Cole 2004.  Docosahexaenoic acid protects from post-synaptic marker loss in an AD model.Neuron. 42:633-45.
• Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA.   NSAID and Antioxidant Prevention of Alzheimer's Disease: Lessons from In Vitro and Animal Models. Ann N Y Acad Sci. 2004  :68-84
• Role of LRP in TGFß2-Mediated Neuronal Uptake of Aß & Effects on Memory ME. Harris-White, Z Balverde, GP. Lim, P Kim, SA. Miller, H Hammer, D Galasko, SA. Frautschy 2004 J Neuroscience Res .  77:217–228.
• JM. Craft, DM Watterson, SA. Frautschy, LJ. Van Eldik  Aminopyridazines inhibit ß-amyloid-induced glial activation and neuronal damage in vivo. 2004.  Neurobiol  Aging 25 (10) 1283-92.
• X Sun, GM Cole, T Chu, W Xia, D Galasko, H Yamaguchi, K Tanemura, SA. Frautschy and A Takashima. 2002  Intracellular Aß is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines. Neurobiology of Aging 23:195-203
• Lim, GP,Chu, T., Yang, F, Beech, W., Frautschy, SA, Cole, GM 2001 The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.  J. Neurosci 21:8370-8377.
• Lim, GP, Yang, F, Chu, T, Gahtan, E, Ubeda,O, Beech, W, Overmier, JB,  Hsiao Ashe K, Frautschy, SA, Cole, GM Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging. 22: (6) nov-dec 2001. 983-981
• Frautschy, S.A., Hu, W., Miller, S.A., Kim, P., Harris-White, M.E., Cole, G.M..  2001. Phenolic Anti-inflammatory Antioxidant reversal of Aß-induced Cognitive Deficits and neuropathology.  Neurobiology of Aging. 22: (6) nov-dec 2001. pp 991-1003
• Harris-White, ME, Chu, T, Miller, SA, Simmons, M, Nash, D, Teter, B, Cole, GM, Frautschy, SA 2001. Estrogen (E2) and Glucocorticoid (Gc) Effects on microglia and Aß Clearance In vitro and In vivo. Neurochemistry International. 39 (5-6):435-448
• Lim, GP, Yang F, Chu T, Chen, P, Beech, W, Teter, B., Tran, T, Ubeda O, Hsiao Ashe K, Frautschy SA, Cole GM  2000.  Ibuprofen reduces inflammation and plaque pathology in a mouse model for Alzheimer’s disease. J Neuroscience;20 5709-5714.
• Cole, G.M., Beech, W. , Frautschy, S.A. , Sigel, J., Glasgow, C., Ard, M.D. Lipoprotein effects on Aß accumulation and degradation by microglia in vitro. J. Neurosci. Res. 1999  57:504-520
• Mega, M.S., Chu, T., Thompson, P.M., Mazziotta, J.C., Trivedi,K.H., Thompson, P.M., Shah, A., Cole, G.M. , Frautschy, S.A., and Toga, A.W. (1999) Amyloid ß protein density and cortical metabolism in FDG-PET in Alzheimer's disease.  1999. Neuroreport 10:2911-2917
• Teter,B.,  Harris-White, M.E., Frautschy,S.A., Cole, G.M. Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures. Neuroscience. 1998 91:1009-1016
• Pannizon, K., Frautschy, S.A., Wallis, R.A.  1998.  BCL-2 peptide inhibits apopotosis from traumatic in hippocampal slices.  Dec. 18. Neuroreport. 9:4131.
• T. Chu, J.J. Sigel, G.M. Cole, S.A. Frautschy. Chloroquine and Leupeptin induce intracellular accumulation of Aß42 in N9 microglial cells and after icv injection into mice. FEBS Letters 436:439-444. 1998.
• Harris-White, M.E., Chu, T., Sigel, J.J., Flanders, K.C., Frautschy, S.A. Effects  TGFßs(1-3) on Aß deposition and inflammation in organotypic hippocampal slice cultures. J. Neurosci. 18:.10366-10374. 1998.
• Frautschy,  S.A., Horn, D.L., Yang,F., Mendoza, J.J., Sigel, J.J., Harris-Whie, M.E., Saido, T.C., Cole, G.M. 1998.  Protease inhibitor co-infusion with amyloid ß-protein results in enhanced deposition and toxicity in rat brain. J. Neurosci. 18(20). 8311-8321.
• Harris-White, M.E., S. Zanotti, S.A. Frautschy. Charles, A. 1998.  Calcium oscillations in murine organotypic hippocampal slices. J. Neurophysiol.,79:1045-1052.
• Yang, F. Sun, X., Beech, W., Teter, B., Wu, S., Sigel, J., Frautschy, S.A., Cole, G.M. (1998) Antibody to Caspase-Cleaved Actin Detects Apoptosis in Differentiated Neuroblastoma and Neurons and Plaque-Associated Neurons and Microglia in Alzheimer’s Disease  American J. Pathology. 152: 379-389. 1998.
• Frautschy, S.A. Yang, F., Irrizarry, M., Hyman, B., Saido, T.C., Hsiao, K., Cole, G.M. Microglial response to amyloid plaques in APPsw transgenic mice. Amer. J., Pathol. 152: 307-317. 1998.
• Frautschy,S.A., Yang, F., Calderón, L., Cole, G.M.  1996. Rodent Model of Alzheimer's Disease: Rat Aß Infusion Approaches to Amyloid Deposits.  Neurobiol of Aging17:311-321.
• Hanneken, A., Frautschy, S.A., Galasko, D. and Baird, A. Soluble Forms of the High Affinity FGF receptor in Cerebral Spinal Fluid.Neuroreport. 6:886-888. 1995.

  Logan, A., M. Berry, A.M. Gonzalez, Frautschy, S.A., M.B. Sporn, and A. Baird.  Effects of TGF ß1 on scar production  in the injured central nervous system of the rat.  Eur. J. Neurosci.  6:355-363. 1994.

  Winkler, J., Connor, D.J., Frautschy, S.A., Behl, C., Waite, J.J., Cole, G.M., Thal, L.J. Lack of Long-Term Effects after beta-amyloid protein injections in rat brain. Neurobiology of Aging 15:601-607. 1994.

•  Frautschy, S.A., G.M. Cole, and A. Baird.  The comparative effects of injury and amyloid injection on Alzheimer’s antigens in the rat brain.  In:  Alzheimer’s Disease: Advances in Clinical and Basic Research.  B. Corain, et al. (eds).  pp. 507-516.  1993.

  Frautschy, S.A., G.M. Cole, and A. Baird.  Phagocytosis and deposition of vascular ß-amyloid in rat brains injected with Alzheimer ß-amyloid.  Am. J. Pathol. 140:1389-1399, 1992.

  Waite, J., G.M. Cole, Frautschy, S.A., D.M. Conner, and L. Thal.  Solvent effects of ß-protein in the rat in vivo.  Neurobiol. Aging 13:595-599, 1992.

• Frautschy, S.A., A. Baird, and G.M. Cole.  Effects of injected Alzheimer-amyloid cores in rat brain.  Proc. Natl. Acad. Sci. USA 88:8362-8366, 1991.